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TranscriptomicsTaf7l Modulates Brown Adipose Tissue Formation
Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (Ucp1). Previously, we reported that the TATA-binding protein Associated Factor 7L (Taf7l) is an important regulator of white adipose tissue (WAT) differen...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-55797 | biostudies-arrayexpress
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
MetabolomicsInsights into Metabolic Changes Caused by the Trichoderma virens-Maize Root Interaction
The interactions of crops with root-colonizing endophytic microorganisms are highly relevant to agriculture, because endophytes can modify plant resistance to pests and increase crop yields. We investigated the interactions between the host plant Zea mays and the endophytic fungus Trichode...
2021-07-08 | MTBLS1964 | MetaboLights
ProteomicsCSF1R-CAR T cells induce CSF1R signaling and promote target cell growth
Chimeric antigen receptor (CAR) T cells have revolutionized the landscape of cancer therapy, demonstrating unprecedented success in treating relapsed or refractory blood cancers. Previous studies of the mechanisms underlying the interactions and responses of CAR T cells and their targets have focuse...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD058576 | Pride
TranscriptomicsTranscription profiling of jejunum from chickens with either a high or low natural antibody response which were fed an organic or conventially produced diet
ISA Brown Warren medium heavy layer hens were divergently selected for 25 generations on their primary immune response. Two selection chicken lines were established: chickens with a high natural antibody response (H) and chicken with a low natural antibody response (L). Besides a control line of ran...
ORGANISM(S): Gallus gallus 
2010-03-02 | E-MEXP-1798 | biostudies-arrayexpress
UnknownAdaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels.
Not available
S-EPMC7779784 | biostudies-literature
TranscriptomicsTranscription profiling of mouse white adipose tissue and brown adipose tissue from Bscl2 knock-out mice and their wild-type control mice
Experiments were designed to compare white adipose tissue (WAT) or brown adipose tissue (BAT) -in male and female mice- between Bscl2 knock-out mice and their wild-type control mice. RNA was pooled to obtain 2x 8µg per tissue source and subjected to dye-swap hybridization.
ORGANISM(S): Mus musculus 
2010-06-09 | E-MARS-18 | biostudies-arrayexpress
ProteomicsCAR T cells inhibit B cell activating phosphorylation in their targets
Adoptive cell therapy, a subset of cancer immunotherapy, is collection of therapeutic approaches which aim to redirect the immune system by reprogramming patient T-cells to target antigenic molecules differentially and specifically expressed in certain cancers. One promising immunotherapy technique ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD028109 | Pride
Cart signaling Phosphoproteomics Phosphotyrosine 
ProteomicsHighly reproducible improved label-free quantitative analysis of cellular phosphoproteome by optimization of LC-MS/MS gradient and analytical column construction
Expanding the sequencing depth of the peptides showing a statistically significant quantitative change arising from a biological stimulation is critical. Here we demonstrate that optimization of LC gradient and analytical column construction can reveal over 30,000 unique peptides and 23,000 phosphop...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005650 | Pride
Human T cell Acute leukemia Q exactive Phosphoproteomics Label free 
TranscriptomicsTranscriptional profiles uncover Aspergillus flavus induced resistance in mature maize kernels
Aflatoxin contamination caused by the opportunistic pathogen A. flavus is a major concern in maize production prior to harvest and during storage. Previous studies indicate that both constitutive and induced resistance are involved in maize kernel defense against A. flavus infection, little is known...
ORGANISM(S): Zea mays 
2010-10-01 | E-GEOD-19883 | biostudies-arrayexpress
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