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MetabolomicsPodophyllotoxin-induced nephrotoxicity via the microbiota-gut-kidney axis in SD rats based on the toxicological evidence chain (TEC) concept
Podophyllotoxin (PPT) exhibits limited clinical utility due to its nephrotoxicity, and its underlying mechanisms remain poorly understood. This study employs the toxicological evidence chain (TEC) framework and integrated multi-omics analyses to investigate the potential involvement of the microbiot...
2026-06-25 | MTBLS14854 | MetaboLights
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of spontaneously hypertensive and Sprague Dawley rat lung tissue from subjects exposed to sulfur dioxide and controls
Chronic obstructive pulmonary disease (COPD) is diagnosed by airway obstruction and underlies a group of ailments such as bronchitis, emphysema and often asthma; however, rodent models do not resemble human pathology. Because genetically predisposed spontaneously hypertensive (SH) rats display pheno...
ORGANISM(S): Rattus norvegicus 
2008-02-23 | E-GEOD-4702 | biostudies-arrayexpress
TranscriptomicsThe Influence of Sleep Deprivation on Hippocampal CA1 Gene Expression: Relation to Stress and Aging
Sleep deprivation (SD) in young adults is associated with metabolic, stress and cognitive responses that are also characteristic of brain aging. Given that sleep architecture changes with age, including increased fragmentation and decreased slow wave activity, it seems reasonable to investigate pote...
ORGANISM(S): Rattus norvegicus 
2012-07-16 | E-GEOD-34424 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hypothalamo-neurohypophyseal system reveals gene expression is highly strain-dependant
We have used microarrays to comprehensively describe the transcriptomes of the supraoptic nucleus (SON), the paraventricular nucleus (PVN) and the neurointermediate lobe (NIL) of adult male Sprague-Dawley (SD) and Wistar-Kyoto (WKY) rats, as well as the paraventricular nucleus of Wistar (WIST) rats....
ORGANISM(S): Rattus norvegicus 
2008-10-25 | E-GEOD-8491 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of clofibrate treated rat livers
5 day q.d. treatment by oral gavage of SD rats using 0, 200, 400 or 800 mg/kg/day of the peroxisome proliferator clofibrate. Livers were removed, RNA was isolated, and Cy3/Cy5 probes generated for 2-channel microarray experiments.
ORGANISM(S): Rattus norvegicus 
2004-01-14 | E-MEXP-3 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae rnt1 mutant and wild type cultures
Strain background is BMA64 with RNT1 gene deleted with the TRP marker Media is SD -Trp (synthetic dextrose minimal media missing tryptophan) Cells were grown until midlog and harvested at OD600=0.4; MAS5 (Statistical Algorithm) Scaling:All Probe Sets Target Signal 500;Normalization:All Probe Sets; A...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-2683 | biostudies-arrayexpress
TranscriptomicsScl-Ab: Exploratory 26-Week Subcutaneous Toxicology Study in the Aged Ovariectomized Female Sprague Dawley Rat with an 18-week Recovery
This study is designed to compare and contrast the temporal and spatial changes in bone formation rates and transcriptional profiles in cortical and cancellous bone cell populations enriched by laser capture microdissection (LCM) in ovariectomized rats administered Scl-Ab by subcutaneous injection f...
ORGANISM(S): Rattus norvegicus 
2016-01-06 | E-GEOD-71306 | biostudies-arrayexpress
TranscriptomicsMolecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 2)
In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabe...
ORGANISM(S): Rattus norvegicus 
2011-08-09 | E-GEOD-23809 | biostudies-arrayexpress
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