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MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
MetabolomicsHyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment

Introduction

Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated w...
2022-02-07 | MTBLS2150 | MetaboLights
MetabolomicsA female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite
ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which, gABCG2, is transcribed predominantly in the gametoc...
2016-09-14 | MTBLS98 | MetaboLights
ModelsMODEL1703310000_url.xml
Ramirez2017 - Human global metabolism in brown and white adipocytes Recon 2.1A, an update to Recon 2.1x, is suitable for quantitatively-realistic results for flux balance analysis in human metabolism. This model is described in the article: Integrating Extracellular Flux Measur...
MODEL1703310000 | BioModels
ProteomicsBrown bear skeletal muscle quantitative LC-MSMS
Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bear...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2019-05-14 | PXD004908 | Pride
Lc-msms Skeletal muscle Hibernation Bears 
ProteomicsBrown bear skeletal muscle 2D-DIGE-LC-MSMS
Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bear...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2019-05-14 | PXD011687 | Pride
Lc-msms Skeletal muscle Hibernation Bears 2d-dige 
UnknownThe Gq signalling pathway inhibits brown and beige adipose tissue.
Not available
S-EPMC4786868 | biostudies-literature
UnknownHibernating brown bears are protected against atherogenic dyslipidemia.
Not available
S-EPMC8455566 | biostudies-literature
TranscriptomicsCellular and molecular evidence for a role of tumor necrosis factor alpha in the ovulatory mechanism of trout
The relevance of immune-endocrine interactions to the regulation of ovarian function in teleosts is virtually unexplored. As part of the innate immune response during infection, a number of cytokines such as tumor necrosis factor α (TNFα) and other immune factors, are produced and act on the repro...
ORGANISM(S): Oncorhynchus mykiss 
2010-05-14 | E-GEOD-20296 | biostudies-arrayexpress
UnknownBrown Carbon from Photo-Oxidation of Glyoxal and SO2 in Aqueous Aerosol.
Not available
S-EPMC10201569 | biostudies-literature
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