Proteomics

Dataset Information

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Brown bear skeletal muscle 2D-DIGE-LC-MSMS


ABSTRACT: Muscle atrophy is one of the main deleterious consequences of ageing and physical inactivity. Although basic knowledge regarding the underlying mechanisms of muscle atrophy is continuously growing, there are still no efficient therapeutic strategies for its prevention and treatment. Hibernating bears exhibit a strong and unique ability to preserve muscle mass in conditions where muscle atrophy is observed in humans. However, underlying mechanisms have not been understood yet. To fill this gap, the aim of this study was to characterize changes in the bear muscle proteome during hibernation versus the active period. Muscle biopsies were obtained from Ursus arctos bears.

INSTRUMENT(S): maXis 4G

ORGANISM(S): Ursus Arctos Arctos (european Brown Bear)

TISSUE(S): Skeletal Muscle

SUBMITTER: Fabrice BERTILE  

LAB HEAD: Sarah Cianférani

PROVIDER: PXD011687 | Pride | 2019-05-14

REPOSITORIES: Pride

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Publications

Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (<i>Ursus Arctos</i>).

Chazarin Blandine B   Ziemianin Anna A   Evans Alina L AL   Meugnier Emmanuelle E   Loizon Emmanuelle E   Chery Isabelle I   Arnemo Jon M JM   Swenson Jon E JE   Gauquelin-Koch Guillemette G   Simon Chantal C   Blanc Stéphane S   Lefai Etienne E   Bertile Fabrice F  

Antioxidants (Basel, Switzerland) 20190822 9


Oxidative stress, which is believed to promote muscle atrophy, has been reported to occur in a few hibernators. However, hibernating bears exhibit efficient energy savings and muscle protein sparing, despite long-term physical inactivity and fasting. We hypothesized that the regulation of the oxidant/antioxidant balance and oxidative stress could favor skeletal muscle maintenance in hibernating brown bears. We showed that increased expressions of cold-inducible proteins CIRBP and RBM3 could favo  ...[more]

Publication: 1/2

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