Brown adipocytes

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Organisms

Mus musculus (281)
Homo sapiens (43)
Mesocricetus auratus (1)
Equus caballus (1)
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Mus (1)
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Repository

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pride (43)
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Tissue

Brown adipose tissue (16)
Brown fat cell (7)
Cell culture (6)
White adipose tissue (4)
Adipose tissue (3)
Brown adipocyte (3)
Liver (3)
Adipose tissue (1)
Adipocyte (1)
Bile (1)
Blood plasma (1)
Brown fat cell differentiation (1)
Brown preadipocyte (1)
Epididymal white adipose tissue (1)
Fat cell (1)
Foreskin fibroblast cell line (1)
HEK-293T cell (1)
Macrophage (1)
Preadipocyte (1)
Primary cell line cell (1)
Subcutaneous adipose tissue (1)
White adipocyte (1)
White fat cell (1)

Disease

Type 2 diabetes mellitus (3)
Obesity (2)
Abdominal aortic aneurysm (1)
Diabetes mellitus (1)
Disease free (1)
Metabolic dysfunction-associated steatotic liver disease (1)

Technology Type

Mass Spectrometry (44)
Shotgun proteomics (21)
Data-dependent acquisition (9)
Mass spectrometry (7)
Bottom-up proteomics (7)
Top-down proteomics (5)
Mass spectrometry assay (3)
NMR spectroscopy (1)
ESI (1)
Affinity purification coupled with mass spectrometry proteomics (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
Data-independent acquisition (1)
Gel-based experiment (1)

Instrument Platform

Illumina NovaSeq 6000 (11)
NextSeq 500 (7)
Illumina HiSeq 2500 (6)
Orbitrap Fusion Lumos (4)
NextSeq 550 (3)
Illumina HiSeq 2000 (3)
Q Exactive (3)
Illumina HiSeq 3000 (2)
Illumina HiSeq 4000 (2)
Orbitrap Exploris 120 (2)
Gas Chromatography MS - positive (2)
Liquid Chromatography MS - alternating - hilic (2)
Liquid Chromatography MS - alternating - reverse phase (2)
Liquid Chromatography MS - negative - reverse phase (2)
Liquid Chromatography MS - positive - reverse phase (2)
Standard laboratory equipment for RNA library construction (1)
Agilent Bioanalyser for RNA quality control (1)
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Not applicable (1)
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ACCRE (1)
BGISEQ-500 (1)
Exploris 480 (1)
Orbitrap Fusion (1)
Q Exactive HF (1)
Q Exactive HF-X (1)
TripleTOF 6600 (1)
Thermo Electron FOCUS GC (1)

Publication Date

2025 (56)
2022 (54)
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2023 (48)
2015 (37)
2018 (29)
2021 (28)
2020 (26)
2019 (24)
2017 (21)
2013 (19)
2014 (17)
2016 (16)
2010 (12)
2011 (10)
2012 (8)
2009 (4)
2007 (4)
2005 (2)
2008 (1)
2006 (1)

CHEBI ID

CHEBI:27823 (2)
CHEBI:18402 (2)
CHEBI:58216 (1)
CHEBI:37636 (1)
CHEBI:37635 (1)
CHEBI:37634 (1)
CHEBI:37632 (1)
CHEBI:58235 (1)
CHEBI:24859 (1)
CHEBI:59908 (1)
CHEBI:16759 (1)
CHEBI:52288 (1)
CHEBI:168308 (1)
CHEBI:8927 (1)
CHEBI:793340 (1)
CHEBI:37480 (1)
CHEBI:57627 (1)
CHEBI:58414 (1)
CHEBI:57660 (1)
CHEBI:58600 (1)
CHEBI:58039 (1)
CHEBI:36986 (1)
CHEBI:45479 (1)
CHEBI:57561 (1)
CHEBI:57632 (1)
CHEBI:58052 (1)
CHEBI:57658 (1)
CHEBI:28146 (1)
CHEBI:57836 (1)
CHEBI:57880 (1)

Metabolite Name

3-Methyl-2-oxovaleric acid (2)
Lactate (2)
AMP (2)
ATP (2)
Beta-alanine (2)
Succinic acid (2)
Glycolic acid (2)
CMP (2)
GMP (2)
UMP (2)
DTMP (2)
Nicotinic acid riboside (1)
3-amino-2-methylpropanoic acid (1)
L-argininosuccinic acid (1)
L-ornithine (1)
L-alanine (1)
L-cysteine (1)
N-formylkynurenine (1)
Indole-3-carboxaldehyde (1)
Glucose 1-phosphate (1)
Cis aconitic acid (1)
2-oxoisovaleric acid (1)
2-Oxoisovaleric acid (1)
M-Hydroxybenzoic acid (1)
2-Hydroxy-4-methylvaleric acid (1)
3-Phenylpropionic acid (1)
2-Deoxyribose 1-phosphate (1)
O-Phosphoserine (1)
Isethionic acid (1)
2-Deoxyglucose 6-phosphate (1)

First Public Date

2025 (50)
2026 (46)
2024 (46)
2022 (45)
2023 (34)
2018 (27)
2014 (26)
2019 (23)
2021 (22)
2020 (22)
2017 (21)
2015 (17)
2016 (9)
2013 (3)

Modelling Approach

Metabolic network (1)
Constraint-based model (1)

Lab affiliation

Department of Molecular & Integrative Physiology,University of Michigan Medical School, 5325 Brehm Tower, 1000 Wall St., Ann Arbor, MI, 48105 (3)
Department Molecular Toxicology, Helmholtz Centre for Environmental Research GmBH - UFZ (2)
Howard Hughes Medical Institute Beth Israel Deaconess Medical Center Harvard Medical School (2)
1 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA 2 Department of Cell Biology, Harvard Medical School, Boston, MA, USA (1)
1 Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA 2 Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA 3 Morgridge Institute for Research, Madison, WI, USA 4 National Center for Quantitative Biology of Complex Systems, Madison, WI, USA (1)
1Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada 2Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada (1)
1Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore 2 Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore 3 Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 4Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 5 Department of Endocrinology, Tan Tock Seng Hospital (TTSH), Singapore (1)
Boston University School of Medicine (1)
Bruce M. Spiegelman, Ph D. Stanley J. Korsmeyer Professor of Cell Biology and Medicine Dana-Farber Cancer Institute, Harvard Medical School bruce_spiegelman@dfci.harvard.edu 617-632-3567 (1)
Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, Gladstone Institutes, University of California San Francisco, CA, USA (1)
Cellular and Molecular Pharmacology, UCSF (1)
Chair of Proteomics and Bioanalytics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany (1)
Dana Farber Cancer Institute, Dept. Cancer Biology; Harvard Medical Schoool, Dept. Cell Biology (1)
Dana-Farber Cancer Institute, Dept. Cancer Biology; Harvard Medical School, Dept. Cell Biology (1)
Dana-Farber Cancer Institute/ Harvard Medical School (1)
Dep. of Health Sciences and Technology, ETH Zurich Schorenstrasse 16, 8603 Schwerzenbach, Switzerland (1)
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA Center for Cancer Research Purdue University, West Lafayette, IN 47907, USA (1)
Department of Biochemistry and Molecular Biomedicine and Institute of Biomedicine 10 (IBUB), University of Barcelona, Barcelona, Spain CIBER “Fisiopatología de la Obesidad y Nutrición”, Instituto de Salud Carlos III, Madrid, Spain (1)
Department of Biology, University of Rome Tor Vergata, Rome, Italy (1)
Department of Cardiovascular & Metabolic Sciences, Cleveland Clinic Foundation, USA (1)
Department of Cell Biology, Harvard Medical School Department of Cancer Biology, Dana-Farber Cancer Institute (1)
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA (1)
Department of Metabolic Medicine, Faculuty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuoku, Kumamoto 860-8556, Japan (1)
ETH Zürich, SLA, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland (1)
German Cancer Research Center DKFZ (1)
Helmholtz Diabetes Center (1)
Helmholtz Diabetes Center Munich (1)
Italian National Institute of Health - Department of Neuroscience (1)
Laboratoire de Spectrométrie de Masse BioOrganique, Analytical Science department, IPHC, CNRS, Strasbourg University, UMR7178, Strasbourg, France (1)
Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China (1)

IsPrivate

False (1)

Model Flag

Non Kinetic (1)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (64)
RNA-seq of coding RNA (29)
ChIP-seq (6)
Animal - High-throughput sequencing (3)
Single nucleus RNA sequencing (3)
RNA-seq of non coding RNA (3)
Animal - Single-cell sequencing (2)
High-throughput sequencing (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of total RNA (2)
Unknown experiment type (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)

Release Date

2021 (127)
2022 (123)
2020 (120)
2023 (109)
2018 (101)
2025 (100)
2019 (98)
2017 (97)
2024 (90)
2016 (80)
2015 (78)
2014 (51)
2013 (40)
2012 (28)
2011 (20)
2026 (16)
2010 (16)
2008 (11)
2009 (9)
2007 (8)
2004 (4)
2005 (3)
2006 (3)
2003 (2)
1999 (1)

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Multi-omics analysis of thermogenic lipolysis in brown adipocytes

The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are conside...

2025-11-12 | MTBLS12307 | MetaboLights

Mitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights

Lipidomics of brown adipocytes treated with d9-choline

Not available

ORGANISM(S): Mus musculus

ST001960 | MetabolomicsWorkbench

Cars2-Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2.

Targeting transcriptional regulatory complexes represents a promising strategy for activating thermogenic fat and treating obesity. In this study, we focused on identifying critical, specific metabolic pathways enriched during brown adipocyte differentiation. Through analysis of metabolomics and RNA...

2026-03-24 | MTBLS12237 | MetaboLights

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...

2022-03-03 | MTBLS2436 | MetaboLights

RNA-seq comparison of primary mouse classical brown, beige, and white adipocytes

Classical brown adipocytes in interscapular BAT (Myf-5 derived) and inducible beige cells in WAT (non-Myf-5 derived) have distinct developmental origins, although both cell types have morphological and biochemical characteristics of brown fat such as the expression of UCP1. This raises an important ...

ORGANISM(S): Mus musculus

2015-03-16 | E-MTAB-2624 | biostudies-arrayexpress

Brown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights

Expression Data from Bone Marrow Progenitor-Derived Adipocytes, White Adipocytes and Brown Adipocytes.

We have identified a population of adipocytes in fat tissue that arise from bone marrow-derived progenitor cells. We used microarrays to compare the global gene expression patterns of the bone marrow progenitor-derived adipocytes as well as conventional white and brown adipocytes to evaluate the rel...

ORGANISM(S): Mus musculus

2010-01-08 | E-GEOD-19757 | biostudies-arrayexpress

MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes

Brown adipose tissue is specialized to burn lipids for heat generation as a natural defense against cold and obesity. Previous studies established microRNAs as essential regulators of brown adipocyte differentiation, but it remains unknown whether microRNAs are required for the feature maintenance o...

ORGANISM(S): Mus musculus

2014-08-07 | E-GEOD-60165 | biostudies-arrayexpress

Next generation sequencing analysis of microRNAs in brown preadipocytes and in vitro differentiated mature brown fat cells

We performed a genome-wide deep sequencing analysis of the microRNAs abundant in mesenchymal stem cells (MSCs) derived from murine brown adipose tissue and in in vitro differentiated mature brown adipocytes. Several microRNAs were identified as differentially regulated when comparing datasets from M...

ORGANISM(S): Mus musculus

2013-05-28 | E-GEOD-45499 | biostudies-arrayexpress

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