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TranscriptomicsSomatic mosaicism for copy number variation in differentiated human tissues
Genetic variation is responsible for the generation of phenotypic diversity, including susceptibility to disease. Two major types of variation are known: single nucleotide polymorphisms (SNPs) and a more recently discovered structural variation, involving changes in copy number (CNVs) of kilobase- t...
ORGANISM(S): Homo sapiens 
2008-09-16 | E-GEOD-9598 | biostudies-arrayexpress
TranscriptomicsPhenotypically concordant and discordant monozygotic twins display different DNA copy number variation profiles (SNP)
The exploration of copy number variation (CNV), notably of somatic cells, is an understudied aspect of genome biology. Any differences in the genetic make-up between twins derived from the same zygote represent an extreme example of somatic variation. We studied 19 pairs of monozygotic twins with ei...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9608 | biostudies-arrayexpress
TranscriptomicsSharp changes in gene expression levels along germinal layers distinguish the development of gyrencephaly
Gyrencephalic species develop folds in the cerebral cortex in a stereotypic manner, but the genetic mechanisms underlying this unique patterning process are unknown. We present a large-scale transcriptomic analysis of individual germinal layers in the developing cortex of the gyrencephalic ferret, c...
ORGANISM(S): Mustela putorius furo 
2015-05-21 | E-GEOD-60687 | biostudies-arrayexpress
TranscriptomicsDevelopment of molecular genetic analysis tools for the domestic ferret (Mustela putorius furo)
The domestic ferret (Mustela putorius furo) has been used as animal model for decades, largely because its susceptibility to infection with a large number of pathogens such as influenza virus, SARS Corona virus and Canine distemper virus. Despite its importance for biomedical research, little is kno...
ORGANISM(S): Mustela putorius furo 
2010-09-13 | E-GEOD-19398 | biostudies-arrayexpress
UnknownFirst genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma.
Not available
S-EPMC4355561 | biostudies-literature
UnknownEvidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis.
Not available
S-EPMC4383727 | biostudies-literature
TranscriptomicsHost Gene Expression Signatures Discriminate between Ferrets Infected with Genetically Similar H1N1 Strains.
Different respiratory viruses induce virus-specific gene expression in the host. Recent evidence, including those presented here, suggests that genetically related isolates of influenza virus induce strain specific host gene regulation in several animal models. Here, we identified systemic strain-sp...
ORGANISM(S): Mustela putorius furo 
2012-06-15 | E-GEOD-28967 | biostudies-arrayexpress
UnknownIncidence of central venous catheter-related bloodstream infections before, during, and after the SARS-CoV-2 pandemic: a registry-based cohort study.
Not available
S-EPMC12690893 | biostudies-literature
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