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TranscriptomicsThe RNA binding protein Arrest (Aret) regulates myofibril maturation in Drosophila flight muscle
In Drosophila, fibrillar flight muscles (IFMs) enable flight, while tubular muscles mediate other body movements. Here, we use RNA-sequencing and isoform-specific reporters to show that spalt major (salm) determines fibrillar muscle physiology by regulating transcription and alternative splicing of ...
ORGANISM(S): Drosophila melanogaster 
2014-12-23 | E-GEOD-63707 | biostudies-arrayexpress
TranscriptomicsEffects of physiological and synthetic IAP antagonism on c-IAP dependent signaling
Cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2) play central roles in signal transduction mediated by numerous receptors that participate in inflammatory and immune responses. In certain pathways, such as activation of NF-kB, their degradation is a major regulatory event and is physiolog...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-GEOD-64927 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins
The human malaria parasite Plasmodium falciparum employs intricate post-transcriptional regulatory mechanisms in different stages of its life cycle. Despite the importance of post-transcriptional regulation, key elements of these processes, namely RNA binding proteins (RBPs), are poorly characterize...
ORGANISM(S): Plasmodium falciparum 
2014-10-23 | E-GEOD-56329 | biostudies-arrayexpress
TranscriptomicsC/EBP? poises B cells for rapid reprogramming into iPS cells [RNA-Seq]
C/EBP? induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBP? accomplishes these effects is unclear. We now found that transient C...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52396 | biostudies-arrayexpress
UnknownMultiple RNA binding domains of Bruno confer recognition of diverse binding sites for translational repression.
Not available
S-EPMC3360078 | biostudies-literature
TranscriptomicsComparative analysis of Bruno-3 gain of function in Drosophila larval muscles
Myotonic dystrophy type 1 (DM1) is a neuro-muscular disorder caused by CTG triplet expansion in the 3'-UTR of the DMPK gene. Mutated transcripts aggregate in muscle nuclei and increase CUGBP1 stability by a not-yet determined mechanism. To assess the involvement of CUGBP1 in DM1, we used Drosophila ...
ORGANISM(S): Drosophila melanogaster 
2017-03-24 | E-MTAB-3231 | biostudies-arrayexpress
GenomicsC/EBPα poises B cells for rapid reprogramming into iPS cells [ChIP-Seq]
C/EBPα induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBPα accomplishes these effects is unclear. We now found that transient C...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-52373 | biostudies-arrayexpress
TranscriptomicsRegulatory role of glycerol in Candida albicans biofilm formation
Biofilm formation on medically implanted devices by Candida albicans poses a significant clinical challenge. Here we compared biofilm-associated gene expression in two clinical C. albicans isolates, SC5314 and WO-1, to identify shared gene regulatory responses that may be functionally relevant. Amon...
ORGANISM(S): Candida albicans 
2013-04-12 | E-GEOD-45141 | biostudies-arrayexpress
UnknownThe Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element.
Not available
S-EPMC434433 | biostudies-literature
TranscriptomicsOvercoming the stochastic phase of iPS cells reprogramming by a pulse of C/EBPα [array]
Somatic cell reprogramming into pluripotent stem cells induced by Oct4, Sox2, Klf4 and Myc (OSKM) occurs at low frequencies and with a considerable delay involving a stochastic phase. In contrast, transdifferentiation of B cells into macrophages induced by C/EBPα is fully efficient and initiated al...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-46321 | biostudies-arrayexpress
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