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GenomicsEZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-04-13 | E-GEOD-62058 | biostudies-arrayexpress
TranscriptomicsInhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-71741 | biostudies-arrayexpress
TranscriptomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71911 | biostudies-arrayexpress
GenomicsEZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation [ChIP-Seq]
Here we report the discovery of highly potent and selective EZH2 small molecule inhibitors, their validation by a cellular thermal shift assay, their application across a large lymphoma cell panel and their efficacy in GCBDLBCL xenograft models. Baseline ChIP-seq measurement of KARPAS-422 cell line ...
ORGANISM(S): Homo sapiens 
2015-04-13 | E-GEOD-62057 | biostudies-arrayexpress
TranscriptomicsEZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation [RNA-Seq]
Here we report the discovery of highly potent and selective EZH2 small molecule inhibitors, their validation by a cellular thermal shift assay, their application across a large lymphoma cell panel and their efficacy in GCBDLBCL xenograft models. RNA-seq of KARPAS-422 cell line RNA, in duplicate, tre...
ORGANISM(S): Homo sapiens 
2015-04-13 | E-GEOD-62056 | biostudies-arrayexpress
GenomicsInhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin [ChIP-Seq]
Examine the distribution of KDM1A and the histone H3K4me2 mark on chromatin following treatment with two distinct classes of KDM1A inhibitors - an irreversible inhibitor (RN-1) and a reversible inhibitor (GSK690) 15 samples total from two treated cell lines - 9 from Kasumi-1 and 6 from SKNO-1. Cont...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-71739 | biostudies-arrayexpress
GenomicsBromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma (ChIP-Seq)
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically validated strategy to modulate oncogenic signaling through selective attenuation of gene expression. Here, we demonstrate that CBP/EP300 bromodomain inhibition preferentially abrogates the viability of multiple mye...
ORGANISM(S): Homo sapiens 
2016-01-05 | E-GEOD-71909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hyperdiploid multiple myeloma compared to non hyperdiploid multiple myeloma
Multiple myeloma is a relatively common B-cell malignancy that is currently incurable. Certain recurrent genetic abnormalities characteristics of different genetic subtypes have been described. Hyperdiploid myeloma characterized by recurrent trisomies is the most common genetic subtypes. However lit...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6477 | biostudies-arrayexpress
Unknown5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity.
Not available
S-EPMC8006537 | biostudies-literature
TranscriptomicsBET bromodomain inhibition suppresses TH17-mediated pathology
IL-17-producing T helper (TH17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is also firmly established that their aberrant generation and activation results in autoimmune conditions. Using a characterized potent and selective small mole...
ORGANISM(S): Mus musculus 
2013-09-20 | E-GEOD-37270 | biostudies-arrayexpress
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