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TranscriptomicsAffymetrix gene expression of Transitional Type-1 B-cells from Wild-type (CBA), Xid and Btk KO mice
Splenic Transitional Type-1 B-cells from CBA wild-type mice, X-linked immunodeficiency mice and Bruton's tyrosine kinase knock-out mice. Two replicates where run on Affymetrix 420 2.0 arrays for CBA wild-type, Xid samples and the Btk KO samples. Bruton's tyrosine kinase (Btk) is a cytoplasmic tyros...
ORGANISM(S): Mus musculus 
2014-01-10 | E-GEOD-53946 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of B cells from Xid mice, Btk knockout and CBA mice to identify genes that are differentially expressed in primary B cells lacking functional Btk gene.
Bruton's tyrosine kinase (Btk) is important for B lymphocyte development. To identify genes that are differentially expressed in primary B cells lacking functional Btk, splenocytes from X-linked immunodeficiency (Xid), Btk knockout (KO) and immunocompetent CBA mice, were used in microarrays containi...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2826 | biostudies-arrayexpress
ProteomicsNovel Brutons Tyrosine Kinase (BTK) substrates for time-resolved luminescence assays
BTK substrate profile determined by treating digest KG-1 cell lysate with alkaline phosphatase followed by recombinant BTK. Samples were enriched with PolyMac phosphoenrichment kits prior to analysis. We have organized our uploaded files into three main folders: 1. BTK KALIP MS raw files: raw mass ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-22 | MSV000088429 | MassIVE
TranscriptomicsRole of IL-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK) in mast cell response to lipopolysaccharide (LPS)
Mast cells are indispensable for LPS-induced septic hypothermia, in which TNF-α plays an essential role to initiate sepsis. Tec family non-receptor tyrosine kinases ITK and BTK regulate mast cell-derived TNF-α in response to allergic antigen, but their role in LPS-induced TNF-α production by mast...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-64287 | biostudies-arrayexpress
ProteomicsConformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
Full-length BTK has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3-SH2-kinase core. Precisely how the BTK N-terminal domains (the Pleckstrin homology/Tec homology (PHTH) domain and the long linker that includes proline-rich ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041657 | Pride
Btk  hdx-ms  hydrogen/deuterium exchange mass spectrometry 
TranscriptomicsModeling the clinical phenotype of BTK inhibition in the mature murine immune system
Using the novel BTK inhibitor PF-303, we model the clinical phenotype of BTK inhibition by systematically examining the impact of PF-303 on the mature immune system in mice autoimmune indications. However, our current knowledge of the role of BTK in immune competence has been gathered in the context...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-56483 | biostudies-arrayexpress
ProteomicsDifferential impact of BTK active site inhibitors on the conformational state of full-length BTK
Bruton’s tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in-class covalent inhibitor of BTK, bind directly to the kinase active site. While effective at blocking the catalytic ac...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD020029 | Pride
Bruton’s tyrosine kinase  ibrutinib  dasatinib  gdc-0853  cc-292  cgi1746  drug resistance  sh2 domain  conformational selection  allostery  hdx-ms  hydrogen deuterium exchange mass spectrometry 
ProteomicsProteomics of Btk haemolymph stimulon
The spore-forming bacterium Bacillus thuringiensis (Bt) of B. cereus group uses toxin-opened breaches at the insect midgut epithelium to infest the haemolymph where it rapidly propagates despite antimicrobial host defences to induce eventually host death by acute septicaemia. The response of Bt to h...
ORGANISM(S): Bacillus thuringiensis serovar kurstaki str. HD73 Bacteria 
2021-11-02 | PXD021830 | Pride
Lc-msms Bacillus thuringiensis Tmt Insect pathogen 
ProteomicsImpact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
Inhibition of Bruton’s tyrosine kinase (BTK) has proven to be highly effective in the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL), autoimmune disorders and multiple sclerosis. Since the approval of the first BTK inhibitor (BTKi), Ibrutinib, several other inhibitors in...
ORGANISM(S): Homo sapiens (Human) 
2024-12-04 | PXD047865 | Pride
Bruton’s tyrosine kinase  kinase inhibitor  drug resistance  allostery  sh2 domain  hydrogen deuterium exchange  hdx-ms 
ProteomicsKinase Impaired BTK Mutations Are Susceptible to Clinical Stage BTK and IKZF1/3 Degrader NX-2127
Here we identify that drug-resistant BTK mutations occur in distinct enzymatic classes, some of which render BTK enzymatically impaired while conferring novel protein-protein interactions to sustain B-cell receptor (BCR) signaling.
ORGANISM(S): Homo sapiens (Human) 
2023-12-09 | PXD039012 | Pride
Kinase dead Btk Phosphoproteomics 
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