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TranscriptomicsDifferential expression of S. coelicolor M145 vs. tdd8 mutants in R5
Differential expression data set of S. coelicolor M145, tdd8 deletion mutant and overexpressed tdd8 mutant cultured in R5. RNA samples were collected at the visual onset Red antibiotic production following by cDNA synthesis and labeling. The hybridization was conducted using DNA 104K microarrays (Su...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2015-06-08 | E-MTAB-2644 | biostudies-arrayexpress
TranscriptomicsCombined transcriptome analysis and polysome profiling of Streptomyces coelicolor MT1110 in SMMS
Total RNA, low ribosome density (LRD) and polysome associated RNA were obtained from parallel S.coelicolor cultures of wild type strain MT1110 grown on solid medium SMMS up to rapid growth phase II. The abundance of each RNA in the total RNA, the LRD or polysome pool was quantified by Cydye labeling...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2018-11-01 | E-MTAB-6206 | biostudies-arrayexpress
TranscriptomicsVitamins D3 and D2 have marked but different global effects on gene expression in a rat oligodendrocyte precursor cell line
We describe the changes in gene expression profile of differentiating rat CG4 oligodendrocyte progenitor cell lines treated with either vitamin D2 or D3. The treatment was initiated in cells pre-differentiated for 2 days (time 0) and the changes in gene expression were monitored at 24 h and 72 h pos...
ORGANISM(S): Rattus norvegicus 
2020-07-26 | E-MTAB-8098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptomyces coelicolor wild type and phP-null mutants at different time points during phosphate starvation
S. coelicolor was grown in low-phosphate concentration R5 liquid medium which facilitated the transition to a phosphate starvation induced stationary phase and the subsequent induction of the PhoP regulon. Global gene expression profiling of a wild-type and a phoP-null mutant was performed using sam...
ORGANISM(S): Streptomyces coelicolor 
2012-08-30 | E-MAXD-51 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Streptomyces coelicolor wild type and phP-null mutants during phosphate starvation to determine binding locations of PhoP
S. coelicolor was grown in low-phosphate concentration R5 liquid medium which facilitated the transition to a phosphate starvation induced stationary phase and the subsequent induction of the PhoP regulon. The genome wide binding locations of PhoP during phosphate starvation were determined by chrom...
ORGANISM(S): Streptomyces coelicolor 
2012-08-30 | E-MAXD-50 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Streptomyces coelicolor M600 bldA deletion mutant vs. wild-type M600 S.coelicolor A3(2) time series
Time-dependent gene expression patterns during development and antibiotic production on solid growth medium (SMM) comparing a M600 bldA deletion mutant with wild-type M600 of S.coelicolor A3(2). Eight time points matched in all three replicates of both wild-type and mutant were picked to span the en...
ORGANISM(S): Streptomyces coelicolor 
2008-06-05 | E-MAXD-27 | biostudies-arrayexpress
TranscriptomicsEffect of sleep restriction on the human transcriptome during extended wakefulness
In a cross balanced design human subjects were given one week of sufficient sleep and insufficient sleep (6 h per day). Following each of these conditions they were then kept awake for a day, a night and the subsequent day. During each of these periods of extended wakefulness 10 blood samples were t...
ORGANISM(S): Homo sapiens 
2013-02-27 | E-GEOD-39445 | biostudies-arrayexpress
TranscriptomicsMistimed sleep disrupts circadian regulation of the human blood transcriptome
22 healthy volunteers without sleep disorders were resident in an environmental scheduling facility and participated in a forced-desynchrony protocol, in which the sleep-wake cycle and the associated fasting-feeding cycle is scheduled to a 28-hour period, of which one third (i.e. 9h 20min) is schedu...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-48113 | biostudies-arrayexpress
TranscriptomicsTranscriptome and translatome landscape of Streptomyces coelicolor M145
We have integrated nucleotide resolution genome-scale measurements of the transcriptome and translatome of the Streptomyces coelicolor A3(2), the model antibiotic-producing actinomycete. Our systematic study determined 3,473 transcription start sites, leading to discovery of a high proportion (~21%)...
ORGANISM(S): Streptomyces coelicolor 
2016-05-28 | E-GEOD-69350 | biostudies-arrayexpress
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