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ProteomicsCombined measurements of proteome and cell turnover reveal the influences of tissue context and pathological aging on protein and organelle lifetimes
The lifespans of proteins can range from moments to years within mammalian tissues. Protein lifespan is relevant to organismal aging, as long-lived proteins can accrue damage over time. It is unclear how protein lifetime is shaped by tissue context, where both cell division and proteolytic degradati...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-21 | PXD033649 | Pride
Proteostasis Mouse Protein turnover Silam Lc-ms/ms 
ProteomicsIn Vivo Protein Turnover Rates in Varying Oxygen Tensions Nominate MYBBP1A as a Novel Mediator of the Hyperoxia Response
Oxygen deprivation and excess are both toxic to mammals. Thus, the ability to adapt to varying oxygen tensions is critical for survival. While the transcriptional response to acute hypoxia has been well-studied, the post-translational effects of hypoxia and hyperoxia have been underexplored. In this...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-06-04 | MSV000092095 | MassIVE
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