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ProteomicsThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
A century ago, influenza A virus (IAV) infection caused the 1918 flu pandemic and killed an estimated 20-40 million people. Pandemic IAV outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular details of this species barrier are incomp...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2019-11-11 | PXD015475 | Pride
Influenza a virus infection 
ProteomicsThe dynamic proteome of influenza A virus infection identifies M segment splicing as a host range determinant
A century ago, influenza A virus (IAV) infection caused the 1918 flu pandemic and killed an estimated 20-40 million people. Pandemic IAV outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular details of this species barrier are incomp...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD015474 | Pride
Influenza a virus Human Avian Newly synthesized proteins 
ProteomicsThe dynamic proteome of Influenza A virus infection
We combined metabolic pulse labeling and quantitative shotgun proteomics to globally monitor protein synthesis upon infection of human cells with a human- and a bird-adapted IAV strain. While production of host proteins was remarkably similar, we observed striking differences in the kinetics of vira...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD011321 | Pride
Influenza Protein de novo synthesis Aha A549 Silac Avian flu Human flu 
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