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TranscriptomicsThe Global Molecular Landscape of dormant Hematopoietic Stem Cells
Rare dormant hematopoietic stem cells (dHSCs) reside at the top of the blood hierarchy harboring the highest long-term reconstitution capacity. However, no markers exist to prospectively identify dHSCs and their molecular identity, as well as the mechanism leading to their activation remains poorly ...
ORGANISM(S): Mus musculus 
2017-05-18 | E-MTAB-4547 | biostudies-arrayexpress
GenomicsRCC_HTA2.0_Buettner2022
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) related to Buettner et al, Genome Med 2022. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.26.0, R version 3.6.1). Probe sets were summarized on the Entrez GeneID level using the annota...
EGAD00010002353 | EGA
ProteomicsInflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Standard cancer therapy targets tumor cells without considering the possible collateral damage on the tumor microenvironment that could impair therapy response. Employing patient-derived tumor organoids and primary stroma cells or a novel murine rectal cancer model, we show that interleukin-1 (IL-1 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-08 | PXD020871 | Pride
Chemoradiotherapy Rectal cancer Matrisome Tmt labeling Extracellular matrix 
GenomicsHigh-throughput single cell gene expression analysis in primary blood stem and progenitor cells identifies new links between key transcriptional regulators
Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors (TFs) in 597 single primary ...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-42518 | biostudies-arrayexpress
ProteomicsInflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Standard cancer therapy targets tumor cells without considering the possible collateral damage on the tumor microenvironment that could impair therapy response. Employing patient-derived tumor organoids and primary stroma cells or a novel murine rectal cancer model, we show that interleukin-1a (IL-1...
ORGANISM(S): Homo sapiens (Human) 
2022-02-08 | PXD030422 | Pride
Chemoradiotherapy Ffpe Rectal cancer Super-silac 
Genomicsena-DATASET-RTL-03-05-2017-12:40:06:735-476 - samples
RNAseq of LC2AD with AD80 or DMSO Plenker et al., Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer
EGAD00001003316 | EGA
GenomicsDrugging the catalytically inactive state of RET kinase in RET-rearranged tumors.
Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. We provide further evidence that current anti-RET drugs may not be potent enough to induce ...
EGAS00001002335 | EGA
UnknownInflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.
Not available
S-EPMC9357150 | biostudies-literature
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