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TranscriptomicsPromoter directionality is controlled by U1 snRNP and polyadenylation signals
Transcription of the mammalian genome is pervasive, but productive transcription outside of protein-coding genes is limited by unknown mechanisms. In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the s...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-46433 | biostudies-arrayexpress
TranscriptomicsEvolutionary dynamics of gene and isoform regulation in mammalian tissues
Most mammalian genes produce multiple distinct mRNAs through alternative splicing, but the extent of splicing conservation is not clear.  To assess tissue-specific transcriptome variation across mammals, we sequenced cDNA from 9 tissues from 4 mammals and one bird in biological triplicate, at unprec...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-41637 | biostudies-arrayexpress
TranscriptomicsExon array analysis of resting and activated primary murine CD4+ T-cells
The stability, localization and translation of mammalian mRNAs are largely determined by sequences in the 3' untranslated region (UTR). Here, we describe a conserved program of increased upstream polyadenylation site usage following activation of primary murine CD4+ T lymphocytes. This program, re...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10666 | biostudies-arrayexpress
UnknownRIPK3 Protects Against Endothelial Activation and Vascular Permeability in a Mouse Model of Ischemia-Reperfusion Injury.
Not available
S-EPMC12696878 | biostudies-literature
UnknownThe impact of the COVID-19 pandemic on primary care physicians and nurses in Nova Scotia: a qualitative exploratory study.
Not available
S-EPMC10035666 | biostudies-literature
UnknownDeclining Comprehensiveness of Services Delivered by Canadian Family Physicians Is Not Driven by Early-Career Physicians.
Not available
S-EPMC10042570 | biostudies-literature
UnknownWater-Soluble Components of Sesame Oil Reduce Inflammation and Atherosclerosis.
Not available
S-EPMC4948257 | biostudies-literature
TranscriptomicsA latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.
MicroRNAs (miRNAs) post-transcriptionally regulate the expression of thousands of distinct mRNAs. While some regulatory interactions help to maintain basal cellular functions, others are likely relevant in more specific settings, such as response to stress. Here we describe such a role for the mir-2...
ORGANISM(S): Mus musculus 
2011-06-18 | E-GEOD-30012 | biostudies-arrayexpress
TranscriptomicsIllumina mRNA-Seq of control and hnRNP H knockdown in 293T cells
Pre-mRNA splicing is regulated through combinatorial activity of RNA motifs including splice sites and splicing regulatory elements (SREs). Here, we show that the activity of a major class of mammalian SREs is highly sensitive to the strength of the adjacent 5' splice site (5'ss) sequence, and that...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-16642 | biostudies-arrayexpress
TranscriptomicsWidespread regulation of translation by elongation pausing in heat shock
RNA-seq and ribosome footprinting libraries of mouse 3T3 and human 293T cellsrelated to Shalgi et al. 2013 36bases paired-end RNA-seq, and ribosome footprinting libraries for: 3T3 cells - Control, 8 hours of mild heat shock (42) and 2 hours of severe heat shock (44) - in replicates, as well as 3T3 ...
ORGANISM(S): Mus musculus 
2013-01-03 | E-GEOD-32060 | biostudies-arrayexpress
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