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ProteomicsDiscovery of a novel antifungal compound, ilicicolin K, through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei
In the quest to discover novel antifungal agents and new antifungal production processes, we investigated the biosynthetic gene cluster (BGC) for ilicicolin H in the fungus Trichoderma reesei. While the BGC is silent under standard cultivation conditions, we achieved to activate it by over-expressi...
ORGANISM(S): Trichoderma reesei 
2025-03-13 | PXD055742 | Pride
Multi-omics Fungi Natural products 
ProteomicsMCM proteins are up-regulated in placentas of women with reduced insulin sensitivity
In the first trimester of pregnancy the human placenta grows rapidly, making it sensitive to changes in the intrauterine environment. To test whether exposure to an environment in utero often associated with obesity modifies placental proteome and function, we performed untargeted proteomics (LC-MS/...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056380 | Pride
Obesity Placenta Mcm-complex Early pregnancy Insulin Oxygen Placenta-growth Dna-damage repair Insulin sensitivity Trophoblast 
ProteomicsBurger_et_al_ilicicolin_metabolomics
In this study, the ilicicolin biosynthetic gene cluster (BGC) in Trichoderma reesei was genetically activated, and a series of gene cluster enzyme deletions were performed. Mycelia were harvested and subjected to polar extraction. The resulting polar extracts were analyzed using an untargeted lipido...
ORGANISM(S): Trichoderma Reesei (ncbitaxon:51453) 
MSV000095813 | MassIVE
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