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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
ProteomicsGlobal phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs
Entry into mitosis is driven by the coordinated phosphorylation of thousands of proteins. For the cell to complete mitosis and divide into two identical daughter cells it must regulate dephosphorylation of these proteins in a highly ordered, temporal manner. There is currently a lack of a complete u...
ORGANISM(S): Homo sapiens (Human) 
2015-06-25 | PXD001559 | Pride
Motif Spindle assembly checkpoint. Mitosis Phosphatase Silac Prc1 Myc Phosphorylation Mitotic exit Kinase Phosphoproteomics 
TranscriptomicsTubal ectopic pregnancy as a model to identify endometrial genes and signaling pathways important in decidualization and regulated by local trophoblast
Gestation-matched endometrium was collected from women with ectopic pregnancy (EP) (n=11) and intrauterine pregnancies (IUP) (n=13). RNA was extracted from the tissue. In addition, tissues were prepared for histological analysis for degree of decidualization. We compared a) the samples from EP that ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-MTAB-680 | biostudies-arrayexpress
ProteomicsIn Cellulo Kinase Screen Identifies Novel MASTL Substrates
MASTL (microtubule-associated serine/threonine kinase-like) has emerged as a critical regulator of mitosis and as a potential oncogene in a variety of cancer types. To date, Arpp-19/ENSA are the only known substrates of MASTL. With the cellular roles of MASTL expanding and increased interest in deve...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD028678 | Pride
Akt Phospho-peptides Silac Agc kinase Kinase Mastl 
ProteomicsHs_MitoticExit_Phos_Silac_IT
Global phosphoproteomic mapping of early mitotic exit in human hela cells, ITCID
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005294 | PeptideAtlas
ProteomicsHs_MitoticExit_Phos_Silac_HCD
Global phosphoproteomic mapping of early mitotic exit in human hela cells, HCD
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005254 | PeptideAtlas
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
MetabolomicsUntargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-09-23 | MTBLS1474 | MetaboLights
MetabolomicsMetabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-inflammatory stimuli either alone or in combination on macropha...
2018-03-13 | MTBLS570 | MetaboLights
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