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ProteomicsDeuterium oxide labeling methods for bulk and single muscle protein synthesis measures, and measures of integrated muscle protein synthesis and breakdown rates
This methodological pilot study explored the feasibility of an integrated tracer approach for simultaneous measurement of human skeletal muscle protein synthesis and breakdown during prolonged deuterium oxide (²H₂O) labelling. Four healthy men completed a five week protocol combining daily oral ²H₂O...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD078552 | Pride
Human Skeletal muscle Protein trunover 
ProteomicsDifferentiation of young and replicatively aged mouse C2C12 muscle cells
Age-related impairments in myoblast differentiation may contribute to reductions in muscle function in older adults but the underlying proteostasis processes are not well understood. We investigated young (P6-10) and replicatively aged (P48-50) C2C12 myoblast cultures during early (0h-24h) and late ...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-27 | PXD029515 | Pride
Mouse Deuterium oxide C2c12 Replicative ageing 
ProteomicsHuman Muscle protein responses to exercise during low carbohydrate availablility
Background. Training with low carbohydrate availability (LCA) has been proposed as an independent determinant of physiological perturbations commonly attributed to low energy availability (LEA) and to increase skeletal muscle oxidative machinery, yet the effects of LCA in isolation from LEA remain u...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077494 | Pride
Human Myofibrillar Muscle Lc-ms/ms 
ProteomicsD2O proteome dynamics in response to energy deficit
Energy deficit has shaped human evolution, and represents a potent physiological stressor associated with improvements in lifespan and healthspan in several species. Preserving locomotive capacity has likely been essential for food procurement and survival from starvation during the hunter-gatherer ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-04 | PXD061267 | Pride
Human Deuterium oxide labelling Skeletal muscle Lc-ms/ms 
ProteomicsExercise-responsive phosphoproteins in the heart
Endurance exercise improves cardiac performance and affords protection against cardiovascular diseases but the signalling events that mediate these benefits are largely unexplored. Phosphorylation is an widely studied post-translational modification involved in intracellular signalling, and to disco...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-08-24 | PXD006646 | Pride
Phosphoproteomics Exercise-response 
UnknownProteomic Profiling Uncovers Sexual Dimorphism in the Muscle Response to Wheel Running Exercise in the FLExDUX4 Murine Model of Facioscapulohumeral Muscular Dystrophy.
Not available
S-EPMC12270670 | biostudies-literature
UnknownProteomic profiling uncovers sexual dimorphism in the muscle response to wheel running exercise in the FLExDUX4 murine model of facioscapulohumeral muscular dystrophy.
Not available
S-EPMC11956996 | biostudies-literature
UnknownLabel-free profiling of skeletal muscle using high-definition mass spectrometry.
Not available
S-EPMC4237019 | biostudies-literature
UnknownLabel-free profiling of white adipose tissue of rats exhibiting high or low levels of intrinsic exercise capacity.
Not available
S-EPMC4500166 | biostudies-literature
UnknownNecessary and sufficient conditions on measurements of quantum channels.
Not available
S-EPMC7209144 | biostudies-literature
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