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ProteomicsMAPK Pathway Inhibition Reshapes Kinase Chemoproteomic Ligandability Reporting on Cellular Activation States
Despite the pivotal role of oncogenic kinases in cancer initiation, progression, and resistance, functional profiling of their conformational states within cells remains challenging. Current methodologies often struggle to capture the dynamic structural features and inhibitor-bound conformations of ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD063040 | Pride
Ia-alkyne Tmt Braf Trametinib Chemoproteomics Mass spectrometry Mek1/2 Vemurafenib Arsq-alkyne Cysteine and lysine ligandability Abpp Click chemistry 
ProteomicsCoordination of nuclear RNA processing by speckle-localized kinase TAOK2
Nuclear speckles are membraneless organelles that act as active splicing hubs especially at sites of high transcription; emerging views of this dynamic subnuclear structure place it as a hub of RNA processing from transcription to export. To manage a complex microcosm of RNA metabolism, nuclear spec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD069089 | Pride
Phosphoproteome Speckle-localized kinase taok2 Nuclear rna processing 
ProteomicsReversible histone deacetylase activity catalyzes lysine acylation
The dynamic modification of proteins by many metabolites suggests an intimate link between energy metabolism and post-translational modifications (PTM). For instance, starvation and low-carbohydrate diets lead to the accumulation of the ketone body, β-hydroxybutyrate (BHB), whose blood concentration...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-04-16 | PXD058840 | Pride
Lysine β-hydroxybutyrylation Post-translational modification 
UnknownConsistent patterns of common species across tropical tree communities.
Not available
S-EPMC10808064 | biostudies-literature
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