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ProteomicsIdentification of sulfhydryl-containing proteins and further evaluation of the selenium- tagged redox homeostasis-regulating proteins:Identification of cysteine sites using competitive rdTOP-ABPP strategy.The competitive rdTOP-ABPP strategy be used to reidentify the cysteine sites labeled by Se-SMs.
The competitive rdTOP-ABPP strategy be used to reidentify the cysteine sites labeled by Se-SMs.
ORGANISM(S): Homo sapiens (Human) 
2023-12-07 | PXD046847 | Pride
Rdtop-abpp ia-alkyne  npsp npss dpds ebselen 
UnknownIsotopically-Labeled Iodoacetamide-Alkyne Probes for Quantitative Cysteine-Reactivity Profiling.
Not available
S-EPMC5841085 | biostudies-literature
ProteomicsMAPK Pathway Inhibition Reshapes Kinase Chemoproteomic Ligandability Reporting on Cellular Activation States
Despite the pivotal role of oncogenic kinases in cancer initiation, progression, and resistance, functional profiling of their conformational states within cells remains challenging. Current methodologies often struggle to capture the dynamic structural features and inhibitor-bound conformations of ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD063040 | Pride
Ia-alkyne Tmt Braf Trametinib Chemoproteomics Mass spectrometry Mek1/2 Vemurafenib Arsq-alkyne Cysteine and lysine ligandability Abpp Click chemistry 
ProteomicsisoDTB-ABPP Cysteine Chemoproteomic Profiling for bigelovin
isoDTB-ABPP Cysteine Chemoproteomic Profiling was used to detect the targets of bigelovin in NLRP3 inflammasome activation. LPS and ATP induced bone marrow derived macrophages were adopted for the experiment in three biological replicates. Cell was treated with DMSO and bigelovin respectively. The c...
ORGANISM(S): Mus Musculus 
PXD053000 |
ProteomicsPrioritization of antimicrobial targets by CRISPR-based oligo recombineering
Nucleophilic amino acids are important in covalent drug development yet underutilized as antimicrobial targets. Over recent years, several chemoproteomic technologies have been developed to mine chemically-accessible residues via their intrinsic reactivity toward electrophilic probes. However, these...
ORGANISM(S): Toxoplasma gondii RH 
2022-10-24 | PXD035658 | Pride
Toxoplasma gondii Oligo recombineering Proteomics 
ProteomicsConditional covalent lethality driven by oncometabolite accumulation
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a cancer predisposition syndrome driven by mutation of the tumor suppressor fumarate hydratase (FH). Inactivation of FH causes accumulation of the electrophilic oncometabolite fumarate. In the absence of methods for reactivation, tumor su...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD033546 | Pride
Oncometabalite Hlrcc Fumarate Chemoproteomics Fumarate hydratase Trmt1 
ProteomicsRapid and high coverage profile of human cysteineome-Figure 6
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023058 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsRapid and high coverage profile of human cysteineome
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023059 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsRapid and high coverage profile of human cysteineome-Figure 1
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023056 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsRapid and high coverage profile of human cysteineome-Figure 2
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023057 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
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