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MetabolomicsDistinct succinate modifying products are clinically diagnostic and prognostic biomarkers for fumarate hydratase deficient renal cell carcinoma

Germline or somatic loss-of-function of fumarate hydratase (FH) predisposes patients to an aggressive form of renal cell carcinoma (RCC). Since other than tumor resection, there is no effective therapy for FH-deficient RCC, a competent method for early diagnosis and for early detection of recurre...

2022-08-12 | MTBLS3628 | MetaboLights
MetabolomicsEffects of Lubabegron Fumarate on Ruminal Fermentation and Microbial Community in a Rumen Simulation System (MS (MTBLS))
Lubabegron fumarate (LBF), a novel β-adrenergic receptor modulator approved to mitigate these emissions, lacks a defined ruminal mode of action. This study aimed to characterise the effects of LBF on in vitro rumen fermentation, microbial ecology, and nitrogen metabolism.
2026-06-12 | MTBLS14756 | MetaboLights
TranscriptomicsTranscription profiling of human fibriods vs. normal myometrium with mutated or wild type fumarate hydratase (FH) gene reveals distinct expression profiles in fumarate-hydratase-deficient uterine fibroids.
A series of gene expression measurements of normal myometrium and uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene.
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2725 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human uterine fibroids with mutated or wild type fumarate hydratase gene
A series of gene expression measurements of uterine fibroids with mutated or wild-type fumarate hydratase (FH) gene.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2152 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the protein succination after fumarate treatment of whole cell extracts from Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) fumarate hydratase-deficient (FH-/-) cells
In brief, TCA-precipitated proteins from whole cell extracts treated with fumarate were urea-denatured, reduced, alkylated, and digested with endoproteinase LysC followed by trypsin. The peptide mixtures were loaded onto microcapillary fused silica columns (100um i.d.), packed with C18 reverse phase...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-03-13 | MSV000082160 | MassIVE
TranscriptomicsMR-1 nitrate sample to fumarate sample
One of the most striking observations in the S. oneidensis genome regarding nitrate respiration is that napC is missing and nrfBCD is degenerated. To gain insights into candidate genes encoding the protein(s) in place of NapC and NrfBCD function, i.e., delivering electrons to NapA and NrfA, transcri...
ORGANISM(S): Shewanella oneidensis MR-1 
2010-05-19 | E-GEOD-11198 | biostudies-arrayexpress
ProteomicsFumarate effect on the Escherichia coli proteome at aerobic and anaerobic growth conditions
The changes in protein composition of E. coli were studied in a global proteomic approach for aerobic growth without or with fumarate as carbon source (glycerol + O2, fumarate + O2, respectively) and anaerobic growth without or with fumarate as carbon source (glycerol + DMSO, glycerol + DMSO + fumar...
ORGANISM(S): Escherichia coli 
2019-11-20 | PXD011760 | Pride
Escherichia coli  fumarate metabolism Aerobic/anaerobic growth  c4-dicarboxylates Lc-udmse 
ProteomicsA chemoproteomic portrait of the oncometabolite fumarate
Hereditary cancer disorders often provide an important window into novel mechanisms supporting tumor growth and survival. Understanding these mechanisms and developing biomarkers to identify their presence thus represents a vital goal. Towards this goal, here we report a chemoproteomic map of the co...
ORGANISM(S): Homo sapiens (Human) 
2018-11-27 | PXD009378 | Pride
Lc-msms Uok262 Fumarate Hereditary leiomyomatosis and renal cell carcinoma (hlrcc) Succination Fumarate hydratase (fh) Cysteine reactivity 
TranscriptomicsGene expression in a Geobacter sulfurreducens strain adapted for faster Fe(III) oxide reduction grown with fumarate as an electron acceptor
Geobacter sulfurreducens PCA was put under selective pressure for rapid Fe(III) oxide reduction. The resultant strain, V1, contained five confirmed mutations and reduced Fe(III) oxide 17 times faster. One of these five mutations inactivates dcuB, a fumarate/succinate antiporter necessary for growth ...
ORGANISM(S): Geobacter sulfurreducens 
2011-04-11 | E-GEOD-21313 | biostudies-arrayexpress
ProteomicsIdentification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveal Actions Independent of Keap1 Activation
The fumarate ester dimethyl fumarate (DMF) has been introduced recently for the treatment of relapsing remitting multiple sclerosis (RRMS), a chronic inflammatory condition resulting in neuronal demyelination and axonal loss. The complete mechanism of DMF action is unknown, but involves the depletio...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2019-02-19 | PXD008314 | Pride
Astrocytes Neurons Chemical modification Dimethyl fumarate 
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