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GenomicsA Cbx8-containing Polycomb complex facilitates gene activation during ES cell differentiation [ChIP-Seq]
Polycomb proteins play an essential role in maintaining the repression of developmental genes in self-renewing embryonic stem cells. The exact mechanism allowing the derepression of polycomb target genes during cell differentiation remains unclear. Here, we show that several differentiation genes tr...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-54052 | biostudies-arrayexpress
ProteomicsInhibition of CBP synergizes with the RNA-dependent mechanisms of azacitidine by limiting protein translation
The nucleotide analogue azacitidine (AZA) interferes with RNA and DNA metabolism and is currently the best treatment option for a subset of patients with high-risk myelodysplastic syndromes. However, only half of treated patients respond and almost all patients that initially respond eventually rela...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD021738 | Pride
Hypomethylating agents  azacitidine  epigenetic regulation  lysine acetyl tranferase inhibitors  creb binding protein / cbp / p300  shrna screen  protein synthesis Clonal hematopoietic disorders Myelodysplastic syndromes  secondary acute myeloid leukemia 
UnknownSynthesis, spectroscopic characterization and thermogravimetric analysis of two series of substituted (metallo)tetraphenylporphyrins.
Not available
S-EPMC5480337 | biostudies-literature
GenomicsMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight in the function of this unique histone variant in embryonic and adult stem cells. Knockdown of macroH2A...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35087 | biostudies-arrayexpress
UnknownPost-Translational Modifications of H2A Histone Variants and Their Role in Cancer.
Not available
S-EPMC5876634 | biostudies-literature
UnknownEpigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy.
Not available
S-EPMC8038780 | biostudies-literature
TranscriptomicsGene regulation by phosphomimetic Myc and retinoic acid
We aimed to investigate the E-box and Max-independent functions of the oncogene Myc in gene regulation and differentiation of leukemic cells. Expression in HL60 leukemic cells of a mutant form of Myc with impaired Max and E-box interaction by replacing the phosphorylation sites of Pak2 kinase to asp...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-24731 | biostudies-arrayexpress
UnknownregioneReloaded: evaluating the association of multiple genomic region sets.
Not available
S-EPMC10681856 | biostudies-literature
ProteomicsANP32B is a macroh2A histone chaperone
Interaction proteomics in cell extracts on tagged macroH2A, either expressed in cells or using recombinant dimers with H2B.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD045696 | Pride
Anp32b Histone chaperone Human Macroh2a 
UnknownProbing the conserved roles of cut in the development and function of optically different insect compound eyes.
Not available
S-EPMC10102356 | biostudies-literature
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