Sort   by:  
 Page size 
MetabolomicsMetabolomic alterations in invasive ductal carcinoma of breast: A comprehensive metabolomic study using tissue and serum samples
Invasive ductal carcinoma (IDC) is the most common type of breast cancer and the leading cause of breast cancer related mortality. In the present study, metabolomic profiles of 72 tissue samples and 146 serum samples were analysed using targeted liquid chromatography multiple reaction monitoring mas...
2018-10-16 | MTBLS552 | MetaboLights
ProteomicsLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, Carr SA, Ebert BL. Science 2014, 343, 301-305. doi:10.1126/science.1244851. Lenalidomide is a drug with clinical efficacy in multiple myeloma an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-26 | MSV000079017 | MassIVE
TranscriptomicsTranscription profiling of mouse BRD2-mediated lymphomas
The dual bromodomain protein Brd2 is closely related to the basal transcription factor TAFII250, which is essential for cyclin A transactivation and mammalian cell cycle progression. In transgenic mice, constitutive lymphoid expression of Brd2 causes a malignancy most similar to human diffuse large ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6136 | biostudies-arrayexpress
TranscriptomicsBacterial Adaptation Through Loss of Function
Transcriptional profiling of mutants with beneficial in-frame null mutations. The goal of the study is to understand how expression of the mutants and their parental strain differs in conditions where the mutations are beneficial. For each of two conditions (media with either glutamine or alanine a...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-08-23 | E-GEOD-30345 | biostudies-arrayexpress
TranscriptomicsGene expression in neonatal NKT cells and lymphoma samples from mice with high E protein levels [Microarray Expression]
Inhibitor of DNA binding proteins (ID), including Id1-4, are transcriptional regulators involved in promoting cell proliferation and survival in various cell types. Although upregulation of Id proteins have been widely reported to be associated with a broad spectrum of tumors, recent studies have id...
ORGANISM(S): Mus musculus 
2017-04-20 | E-GEOD-73864 | biostudies-arrayexpress
TranscriptomicsIdentifying mRNA targets of microRNA in clear cell renal cell carcinoma
A bioinformatic approach to identify targets of microRNA in cancer. Keywords: Patient sample study Samples GSM413237-GSM413270: Total RNA from 17 RCC tumors and 17 corresponding non-tumor samples was hybridized against a common reference RNA (Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-16441 | biostudies-arrayexpress
TranscriptomicsControl of expression noise, fitness and gene aggregation by a component of the yeast pheromone response pathway
Cellular processes are subject to variability, or noise, yet mechanisms that promote cell-to-cell uniformity are poorly understood. We have identified such a role for Dig1, a redundant (with Dig2) MAPK-responsive inhibitor of the S. cerevisiae mating pathway transcription factor Ste12. Cells lacki...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-15 | E-GEOD-17583 | biostudies-arrayexpress
TranscriptomicsDexamethasone and lenalidomide have distinct functional effects on erythropoiesis
We explored the effects of dexamethasone and lenalidomide, individually and in combination, on the differentiation of primary human bone marrow progenitor cells in vitro. Both agents promote erythropoiesis, increasing the absolute number of erythroid cells produced from normal CD34+ cells and from ...
ORGANISM(S): Homo sapiens 
2011-04-28 | E-GEOD-28896 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat epididymal fat tissues from diet induced obesity model against lean controls
Analysis of gene expression profiles of epididymal fat from DIO rats; We applied a comparative functional genomics approach to evaluate diet-induced obese (DIO) rats as an obesity model Experiment Overall Design: Gene expression profiles from DIO and lean rats were generated and compared. A private ...
ORGANISM(S): Rattus norvegicus 
2009-04-23 | E-GEOD-8700 | biostudies-arrayexpress
OtherLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Data from Massive, ID: MSV000079017. Experiment: KGG, Rep2, file: G20121009_NU_Ebert_KGG_L-1uMLen_M-No_H-20uMThal_Rep02_bRPFxn06.mzml. Published as part of Science. 2014 Jan 17;343(6168):301-5 . From the Abstract: {{i}} Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B c...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310006306 | GPMDB
Resource Reanalysis 
Sort   by:  
 Page size