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MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
Proteomicsc-di-GMP-induced conformational dynamics of the c-di-GMP-binding protein A (CdbA) from Myxococcus xanthus
The second messenger c-di-GMP has important functions in response to changing environmental and cellular cues in bacteria. Here, we report the identification of CdbA, a DNA binding protein of the ribbon-helix-helix family in Myxococcus xanthus, and show that it binds c-di-GMP in vitro. CdbA is essen...
ORGANISM(S): Myxococcus xanthus DK 1622 
2020-04-16 | PXD018028 | Pride
C-di-gmp Plgs Hdx-ms Dynamx 
ProteomicsA WYL transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP
The WYL transcription factor (LP_RS00300) is a c-di-GMP effector in L. plantarum WCFS1. LP_RS00300 binds to a special motif within the coding sequence, impeding the transcriptional elongation of LP_RS05345 and LP_RS05225, which encode mucus binding proteins (MucBPs). The perception of c-di-GMP by th...
ORGANISM(S): Lactobacillus plantarum WCFS1 Bacteria 
2025-02-14 | PXD053948 | Pride
C-di-gmp receptor Wyl transcription factor Lactiplantibacillus plantarum 
TranscriptomicsVibrio vulnificus: normal intracellular c-di-GMP level vs. high intracellular c-di-GMP level
The profiles of transcripts from the V. vulnificus grown under normal and high c-di-GMP conditions were compared by using a V. vulnificus whole-genome microarray Two-condition experiment, normal c-di-GMP condition vs. high c-di-GMP condition. Biological replicates: 3 control, 3 experimental, indepe...
ORGANISM(S): Vibrio vulnificus CMCP6 
2013-10-22 | E-GEOD-51459 | biostudies-arrayexpress
TranscriptomicsBacterial c-di-GMP reorganizes hematopoietic stem/progenitors and niches through STING
Upon systemic bacterial infection, hematopoietic stem and progenitor cells (HSPCs) migrate to the periphery in order to supply a sufficient number of immune cells. Although pathogen-associated molecular patterns (PAMPs) reportedly mediate HSPC activation, how HSPCs detect pathogen invasion in vivo r...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65905 | biostudies-arrayexpress
TranscriptomicsDiscovery of the genes controlled by the second messenger cyclic di-GMP in Mycobacterium tuberculosis
Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many biological processes in bacteria. The genome in Mycobacterium tuberculosis encodes a single copy of the diguanylate cyclase gene (dgc) responsible for c-di-GMP synthesis. To determine the role of c-di-GMP signaling in M. t...
ORGANISM(S): Mycobacterium tuberculosis 
2013-10-09 | E-GEOD-37973 | biostudies-arrayexpress
GenomicsRegulation of cyanobacterial type IV pilus-dependent functions by interaction between a c-di-GMP receptor and two transcription factors
Regulation of cyanobacterial type IV pilus-dependent functions by interaction between a c-di-GMP receptor and two transcription factors
PRJNA1430694 | ENA
TranscriptomicsEffect of elevated c-di-GMP in Sinorhizobium meliloti
Sinorhizobium meliloti is a soil-dwelling symbiotic alphaproteobacterium. Cyclic di-GMP is an important second messenger controlling multiple functions in this microorganism. To understand transcriptional regulation by elevated c-di-GMP in S. meliloti, the transcriptome analysis was performed on the...
ORGANISM(S): Sinorhizobium meliloti 
2017-06-01 | E-MTAB-5410 | biostudies-arrayexpress
TranscriptomicsRegulation of cyanobacterial type IV pilus-dependent functions by interaction between a c-di-GMP receptor and two transcription factors
Cyanobacteria utilize type IV pili for many behavioural responses, such as phototaxis, aggregation, floating, and DNA uptake. Type IV pilus-dependent functions are regulated by the nucleotide second messengers, c-di-GMP and cAMP. In this study, we investigated the role of a recently identified c-di-...
ORGANISM(S): Synechocystis sp. PCC 6803 
2026-07-03 | GSE322604 | GEO
UnknownStructural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX.
Not available
S-EPMC2747306 | biostudies-literature
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