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UnknownFinal 36-Month Outcomes from the Multicenter DynamX Study Evaluating a Novel Thin-Strut Novolimus-Eluting Coronary Bioadaptor System and Supporting Preclinical Data.
Not available
S-EPMC11266769 | biostudies-literature
UnknownThe MAASWERP Study: An International, Comparative Case Study on Measuring Biomechanics of the Aged Murine Aorta.
Not available
S-EPMC11666261 | biostudies-literature
Proteomicsc-di-GMP-induced conformational dynamics of the c-di-GMP-binding protein A (CdbA) from Myxococcus xanthus
The second messenger c-di-GMP has important functions in response to changing environmental and cellular cues in bacteria. Here, we report the identification of CdbA, a DNA binding protein of the ribbon-helix-helix family in Myxococcus xanthus, and show that it binds c-di-GMP in vitro. CdbA is essen...
ORGANISM(S): Myxococcus xanthus DK 1622 
2020-04-16 | PXD018028 | Pride
C-di-gmp Plgs Hdx-ms Dynamx 
ProteomicsMultisite phosphorylation of intrinsically disordered region of Dishevelled
When WNT binds to its receptor Frizzled (FZD) to activate the signaling, Dishevelled (DVL), the central component of Wnt signaling, is phosphorylated by redundant Casein kinase 1 (CK1) isoforms ε or δ, to transduce the signal downstream. Although the basic principles of Wnt signal transduction are k...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2026-04-07 | PXD063470 | Pride
Dishevelled Phosphorylation Hdx-ms 
UnknownDeuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry.
Not available
S-EPMC6736138 | biostudies-literature
ProteomicsProtection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family
The 33 members of the transforming growth factor beta (TGF-β) family are fundamentally important for organismal development and homeostasis. Family members are synthesized and secreted as pro-complexes of non-covalently associated prodomains and growth factors (GF). Pro-complexes from a subset of fa...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD026841 | Pride
Transforming growth factor beta (tgf‐β) Bone morphogenetic protein (bmp) Electron microscopy (em) Hydrogen exchange mass spectrometry Activin 
ProteomicsDynamics of integrin α5β1, fibronectin, and their complex
Integrin α5β1 mediates cell adhesion to the extracellular matrix (ECM) by binding fibronectin (Fn). Selectivity for Fn by α5β1 is achieved through recognition of an RGD motif in the 10th type-III Fn domain (Fn10) and the synergy site in the 9th type-III Fn domain (Fn9). However, details of the inter...
ORGANISM(S): Homo sapiens (Human) 
2022-08-09 | PXD031508 | Pride
Integrin Thermal stability Conformational change Hydrogen deuterium exchange Fibronectin Affinity 
ProteomicsOral delivery of a cholera toxin-binding protein protects against diarrhoea in experimental cholera
Oral cholera vaccines (OCVs) have become important components of strategies for cholera control, but the demand for OCVs has outstripped the supply2–4. There is a need for new cholera control measures for the one billion people living in cholera endemic regions5. The use of orally delivered single-d...
ORGANISM(S): Vibrio cholerae H1 
2025-02-24 | PXD057713 | Pride
Ctxb Hdx 
ProteomicsThe structural basis of the multi-step allosteric activation of Aurora B kinase
Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear how these phosphorylations activate the ...
ORGANISM(S): Xenopus cf. laevis UF 185698 
2023-05-31 | PXD038935 | Pride
Xenopus laevis Hdx-ms Aurora b 
UnknownFirst randomised controlled trial comparing the sirolimus-eluting bioadaptor with the zotarolimus-eluting drug-eluting stent in patients with de novo coronary artery lesions: 12-month clinical and imaging data from the multi-centre, international, BIODAPTOR-RCT.
Not available
S-EPMC10725075 | biostudies-literature
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