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TranscriptomicsHost cell-free growth of the Q fever bacterium Coxiella burnetii
The inability to propagate obligate intracellular pathogens under axenic (host cell-free) culture conditions imposes severe experimental constraints that have negatively impacted progress in understanding pathogen virulence and disease mechanisms. Coxiella burnetii, the causative agent of human Q (Q...
ORGANISM(S): Coxiella burnetii 
2010-06-20 | E-GEOD-13338 | biostudies-arrayexpress
TranscriptomicsCoxiella burnetii, the agent of Q fever, persists in adipocytes
Coxiella burnetii, the agent of Q fever, persists in humans despite specific immune responses: however, its reservoir remains unknown. We detected C. burnetii in adipose tissue from BALB/c and C57/BL6 mice 4 months after infection when no bacteria were found in other tissues. C. burnetii infected cu...
ORGANISM(S): Mus musculus 
2014-05-25 | E-GEOD-46335 | biostudies-arrayexpress
TranscriptomicsDevelopmental transitions of Coxiella burnetii grown in axenic media
Coxiella burnetii undergoes a biphasic developmental cycle within its host cell that generates morphologically and physiologically distinct large cell variants (LCV) and small cell variants (SCV). During the lag phase of the C. burnetii growth cycle, non-replicating SCV differentiate into replicati...
ORGANISM(S): Coxiella burnetii 
2013-12-02 | E-GEOD-51135 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human BeWo trophoblasts stimulated with Coxiella burnetii, the agent of Q fever
The transcriptional response of BeWo cells stimulated with C. burnetii was analyzed using microarrays covering the whole human genome.
ORGANISM(S): Homo sapiens 
2011-06-01 | E-MEXP-2800 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 25 Coxiella burnetii isolates relative to the Nine Mile (RSA493) reference isolate
Analysis of genetic diversity of 25 Coxiella burnetii isolates with relative to the Nine Mile (RSA493) reference isolate.
ORGANISM(S): Coxiella burnetii 
2006-10-30 | E-TABM-35 | biostudies-arrayexpress
TranscriptomicsSex-related differences in gene expression following Coxiella burnetii infection: potential role of circadian rhythm
Q fever, a zoonosis due to Coxiella burnetii infection, exhibits sexual dimorphism; men are affected more frequently and severely than women for a given exposure. Here we explore whether the severity of C. burnetii infection in mice is related to differences in male and female gene expression profil...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-21065 | biostudies-arrayexpress
ProteomicsTolerant Coxiella burnetii survives doxycycline stress: Proteomics reveals crucial mechanisms
Coxiella burnetii is an intracellular pathogen that causes Q fever, a zoonotic disease found worldwide. In humans, the bacterium is responsible for an acute and chronic disease. It is transmitted to humans by the inhalation of aerosols or contaminated dust containing bacteria from infected livestock...
ORGANISM(S): Coxiella burnetii RSA 331 
2019-08-14 | PXD010250 | Pride
Axenic medium Two-dimensional gel electrophoresis Q fever Enzymatic antioxidants Antibiotic Cell envelope homeostasis 
TranscriptomicsGenotyping of Coxiella burnetii strains collection
Genotyping based on genomic comparative hybridization of different isolates of coxiella burnetii compared to NMI reference strain Two-condition experiment, NMI vs. isolates. One replicate per isolate.
ORGANISM(S): Coxiella burnetii 
2011-12-31 | E-GEOD-31543 | biostudies-arrayexpress
TranscriptomicsEarly response of Coxiella burnetii to temperature stress
Transcriptional profiling of Coxiella burnetii phase I (RSA 493) submitting either to Cold and Heat shock comparing to control untreated Coxiella burnetii phase I (RSA 493) grown at 35°C. Four experiments : Cold shock 30 min Vs 35°C; Cold shock 60 min Vs 35°C; Heat shock 30 min Vs 35°C; Heat sho...
ORGANISM(S): Coxiella burnetii 
2011-01-01 | E-GEOD-21778 | biostudies-arrayexpress
ProteomicsQuantitative proteome profiling of Coxiella burnetii reveals major metabolic and stress differences under axenic and cell culture cultivation – proteome dataset
Coxiella burnetii, a category B select agent, is endemic worldwide, except New Zealand. It causes annually several outbreaks of the zoonotic disease Q fever predominantly in small ruminants. To date, the lipopolysaccharide (LPS), besides a type IV secretion system (T4SS), is the only defined and cha...
ORGANISM(S): Mus musculus (Mouse) Coxiella burnetii Coxiella burnetii RSA 493 
2019-10-24 | PXD013224 | Pride
Lipopolysaccharide Type iv secretion system Q-exactive Dot/icm Stress response Axenic culture Metabolic activity Quantitative proteomics Coxiella burnetii 
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