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ProteomicsC19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germline
In the male mouse germline, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide DNA methylation of young active transposons through SPOCD1. However, the underlying mechanisms of SPOCD1-mediated piRNA-directed transposon methylation and whether this pathway functions to pr...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-14 | PXD047331 | Pride
C19orf84 Spocd1 Pirna Dna methylation 
UnknownC19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line.
Not available
S-EPMC10960678 | biostudies-literature
GenomicsC19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
PRJNA818177 | ENA
GenomicsC19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germline
C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germline
PRJEB51968 | ENA
TranscriptomicsC19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
In the male mouse germline, PIWI-interacting RNAs (piRNAs) bound to the PIWI protein MIWI2 guide the DNA methylation of young active transposable elements (TEs) through SPOCD1. We identified loss-of-function variants in the human SPOCD1 gene that cause male infertility and defective TE silencing. On...
ORGANISM(S): Mus musculus 
2024-02-11 | GSE199038 | GEO
GenomicsC19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germline
In the male mouse germline, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide the DNA methylation of young active transposable elements (TEs) through SPOCD1. We identified loss-of-function variants in human SPOCD1 that cause male infertility and defective TE silencing. ...
ORGANISM(S): Mus musculus 
2024-02-13 | E-MTAB-11612 | biostudies-arrayexpress
GenomicsWhole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice
In the male mouse germline, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide the DNA methylation of young active transposable elements (TEs) through SPOCD1. We find that SPOCD1 interacts with the nuclear pore protein TPR, and that this interaction is required to preven...
ORGANISM(S): Mus musculus 
2025-11-12 | E-MTAB-14862 | biostudies-arrayexpress
GenomicsWhole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice
Whole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice
PRJEB86017 | ENA
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