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GenomicsIFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A
IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A
PRJNA1178560 | ENA
TranscriptomicsIFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A
Keloid is benign skin tumor, and their curing is relatively difficult due to the unclear mechanism of formation. Inducing ferroptosis of keloid fibroblasts (KFs) may become a new method for treating keloid. Here, we discover interferon (IFN)γ could induce KFs ferroptosis through inhibiting SPOC doma...
ORGANISM(S): Homo sapiens 
2025-01-22 | GSE280420 | GEO
UnknownPrognostic Biomarker SPOCD1 and Its Correlation with Immune Infiltrates in Colorectal Cancer.
Not available
S-EPMC9953389 | biostudies-literature
UnknownSPOCD1 promotes the proliferation and metastasis of glioma cells by up-regulating PTX3.
Not available
S-EPMC5934553 | biostudies-literature
UnknownIFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A.
Not available
S-EPMC11739694 | biostudies-literature
UnknownSPOCD1 expression in clear cell renal cell carcinoma: its implications for the prognosis and immunotherapy.
Not available
S-EPMC12523094 | biostudies-literature
ProteomicsA nowhere-to-hide mechanism ensures complete piRNA-directed LINE1 methylation
The mouse PIWI-interacting RNA (piRNA) pathway provides anti-transposon immunity to the developing male germline by directing transposon DNA methylation. The first step in this process is the recruitment of SPOCD1 to young LINE1 loci 1 followed in the second step by piRNA-mediated tethering of the P...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD060850 | Pride
Piwi proteins Pirna Spocd1 and tpr Germline Transposons 
UnknownSPOCD1 is an essential executor of piRNA-directed de novo DNA methylation.
Not available
S-EPMC7612247 | biostudies-literature
UnknownPrognostic Value of SPOCD1 in Esophageal Squamous Cell Carcinoma: A Comprehensive Study Based on Bioinformatics and Validation.
Not available
S-EPMC9130929 | biostudies-literature
GenomicsSPOCD1 is a novel executor of piRNA-directed DNA methylation that links MIWI2 to the de novo DNA methylation machinery
SPOCD1 is a novel executor of piRNA-directed DNA methylation that links MIWI2 to the de novo DNA methylation machinery
PRJNA543424 | ENA
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