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TranscriptomicsLeukemia Inhibitory Factor in C26 Cancer Cachexia
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer. C2C12 myotubes treated with conditioned mediu...
ORGANISM(S): Mus musculus 
2015-06-25 | E-GEOD-68827 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of skeletal muscle gene expression in mice with C26 tumor-induced muscle wasting and cachexia
Analysis of gene expression in CD2F1 mice with cancer cachexia due to implantation of C26 colon carcinoma cells. Total RNA obtained from quadriceps muscle of female CD2F1 mice with early weight loss (10%) or severe weight loss (15%) due to intrascapular subcutaneous implantation of one million C26 c...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-24112 | biostudies-arrayexpress
ProteomicsProteomic comparison study between cancer cachexia muscle of C26 and CT mice
Background Loss of skeletal muscle mass in advanced cancer is recognized as an independent predictor of mortality. Mechanisms involved in this wasting process and parameters for early diagnosis are still lacking. As skeletal muscle is considered as a secretory organ, the aim of this present experime...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-28 | PXD016474 | Pride
Cancer Biomarkers C26 mice Cachexia Muscle Atrophy 
GenomicsWhole hepatic transcriptomic analysis of C26 cachectic mice treated or not with cholestyramine
Whole hepatic transcriptomic analysis of C26 cachectic mice treated or not with cholestyramine
PRJNA645433 | ENA
GenomicsNext Generation Sequencing of mRNA of cachectic mice muscles in C26 model
Next Generation Sequencing of mRNA of cachectic mice muscles in C26 model
PRJNA732917 | ENA
TranscriptomicsGene Expression upon Doxorubicin Treatments
Murine C26 tumor xenografts displayed different responses to the treatments of PBS, Doxorubicin (Dox), and chimeric polypeptide (CP)-Dox conjugates. We used microarrays to globally study gene expression underlying these different responses and identified distinct classes of up-regulated or down-regu...
ORGANISM(S): Mus musculus 
2010-07-15 | E-GEOD-17115 | biostudies-arrayexpress
ProteomicsCarnosol alleviating C26 induced Cancer Cachexia
Shotgun proteomics using LC-high resolution tandem mass spectrometry was applied to check the protein expression profiles of C2C12 myotubes in control group (treated with solvent control 0.1% DMSO), C26 medium group (treated with conditioned medium of C26 tumor cells for 48 h), CS group (treated wit...
ORGANISM(S): Mus Musculus 
2023-07-02 | PXD043464 |
TranscriptomicsCancer-induced Muscle Wasting is IKKM-NM-2-dependent and NF-kappaB-independent
Existing data suggest that NF-kappaB signaling is a key regulator of cancer-induced skeletal muscle wasting. However, identification of the components of this signaling pathway and of the NF-M-NM-:B transcription factors that regulate wasting is far from complete. In muscles of C26 tumor bearing m...
ORGANISM(S): Mus musculus 
2013-11-15 | E-GEOD-48363 | biostudies-arrayexpress
UnknownTrabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia.
Not available
S-EPMC7463843 | biostudies-literature
TranscriptomicsHypothalamic gene expression of appetite regulators in a cancer-cachectic mouse model [Dataset 2]
Appetite is frequently affected in cancer patients, leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer cachectic mouse model with increased food intake. In this model, mice bearing C26 colon adenocarcinoma have ...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-44081 | biostudies-arrayexpress
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