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ProteomicsSalivary proteomics of sP and sNP rats
Sardinian alcohol-preferring (sP) and Sardinina alcohol-non preferring (sNP) rats have been selectively bred for opposite alcohol preference and consumption. The project proposed to identify salivary markers distinguishing the two rat lines possibly correlated to alcohol preference, by a proteomic a...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-11-03 | PXD006997 | Pride
Saliva submandibular rat alcohol-preferring 
ProteomicsMapping of transglutaminase 2 active sites of human salivary small basic proline-rich
Due to the distinctive features of oral mucosa, determination of the proteins involved in the formation of “oral protein pellicle” is demanding. The present study investigated the susceptibility of several human basic proline-rich peptides (bPRPs) named P-H, P-D, P-F, P-J, and II-2 as substrates of ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-25 | PXD014658 | Pride
Bprps Saliva Transglutaminase 2 Human 
ProteomicsNucleotide pyrophosphatase/phosphodiesterase from Euphorbia characias latex
The low-resolution structure of a nucleotide pyrophosphatase/phosphodiesterase from Euphorbia characias latex (ELNPP) has been determined in solution by means of Small Angle X-ray Scattering (SAXS). To improve the structural resolution of ELNPP a partial sequencing after proteolytic cleavage of the ...
ORGANISM(S): Euphorbia characias 
2022-03-02 | PXD009976 | Pride
Nucleotide pyrophosphatase/phosphodiesterase Euphorbia characias Msms sequencing 
ProteomicsTbeta4 identification CaCo2 cells
The paper describes new experiments about thymosin beta 4 nuclear translocation using different in vitro cellular stress in CaCo2 cell line adding new details regarding the role of this peptide during adaptive and defensive response. To this purpose, CaCo2 cells were submitted to different stress tr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD012161 | Pride
Caco2 Thymisin beta4 
ProteomicsCharacterization of novel human cystatin B salivary interactome in Alzheimer’s disease and healthy subjects.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the elderly, characterized by the accumulation in the brain of misfolded proteins, inflammation, and oxidative damage leading to neuronal cell death. The necessity of searching for new non-invasive biomarkers in tissues or b...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030679 | Pride
Coip Proteomics Alzheimer Cystatinb Lc-msms Interactome 
ProteomicsCharacterization of novel human cystatin B salivary interactome in Alzheimer’s disease and healthy subjects.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the elderly, characterized by the accumulation in the brain of misfolded proteins, inflammation, and oxidative damage leading to neuronal cell death. The necessity of searching for new non-invasive biomarkers in tissues or b...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039286 | Pride
Coip Proteomics Alzheimer Cystatinb Lc-msms Interactome 
ProteomicsHuman salivary basic proline-rich proteins
Human basic proline-rich proteins and basic glycosylated proline-rich proteins are the most complex family of human adult salivary proteins, secreted only by the parotid gland, expressed by the polymorphic PRB1-4 genes. This study reports the results obtained for their characterization in our labora...
ORGANISM(S): Homo sapiens (Human) 
2018-08-08 | PXD009813 | Pride
Human High-resolution esi−ms/ms experiments Saliva 
ProteomicsTop-down proteomics of human saliva in Alzheimer disease
Alzheimer disease (AD) is the most prevalent neurodegenerative disease and form of dementia in the elderly. It is characterized by the accumulation in the brain of misfolded proteins, inflammation and oxidative damage leading to region-specific loss of synaptic contacts and neuronal cell death. In t...
ORGANISM(S): Homo sapiens (Human) 
2021-05-24 | PXD021538 | Pride
S100a Salivary proteomics Alzheimer disease Oxidative stress Cystatins Α-defensins Antimicrobial peptides Thymosin β4 
ProteomicsHigh-throughput proteomics and statistical approach identify a protein panel of potential biomarkers of colorectal cancer categorizing intra-tumoral heterogeneity
Colorectal cancer (CRC) is one of the major causes of cancer-related death worldwide, for which diagnosis and prognosis are still inadequate mainly due to local recurrence and metastasis, although medical and surgical treatment in cancer therapy advanced. Diagnosis is frequently late, the high capac...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD050863 | Pride
Proteomics Colorectal cancer Biomarkers Lc-msms 
ProteomicsHPLC-ESI-MS PROFILE OF SALIVARY PROTEINS IN MASTOCYTOSIS PATIENTS
Mastocytosis is a myeloproliferative neoplasm characterized by infiltration of clonally derived mast cells in different tissues. According to mast cells localization, it is possible to discriminate cutaneous mastocytosis (CM) from systemic mastocytosis (SM), the latter involving at least an extracut...
ORGANISM(S): Homo sapiens (Human) 
2020-06-25 | PXD017759 | Pride
Hplc-msms Mastocytosis Salivary proteins 
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