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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
MetabolomicsLiver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma

Paraoxonase-1 (PON1) is specifically expressed in the liver and has crucial effects on various liver diseases. The functions and mechanisms underlying of PON1 in hepatocellular carcinoma (HCC) remain obscure. Here, we show that PON1 acts as a metabolic regulator to mitigate regulatory T (Treg) ce...

2025-09-07 | MTBLS12950 | MetaboLights
MetabolomicsFerritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights
ProteomicsTarget of Dleu2-17aa in CD4+ T cells
To identify Dleu2-17aa micropeptide interacting proteins in CD4+ T cells, we performed pull-down assays fllowed by LC-MS using biotin-labeled Dleu2-17aa. As controls, we included the unlabeled free Dleu2-17aa and a biotin-only group. Pull-downs were carried out in both primary mouse CD4+ T cells and...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-23 | PXD046468 | Pride
Cd4+ t cells Micropeptide 
ProteomicsPolymorphisms of the vitamin D receptor regulate T cells and T cell dependent inflammatory diseases
Complex autoimmune diseases have proven difficult to dissect down to their causative genetic mechanisms. As a result, epidemiological data from different human association studies are often merged to arrive at a working hypothesis. In one of such examples, lack of sun exposure and consequent lower s...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-28 | PXD019876 | Pride
T cell Inflammatory disease Vitamin d3 
TranscriptomicsscRNA-seq data related to Booster mRNA vaccination post-SARS-CoV-2 infection enhances functional qualities of T cell immunity
We performed a study investigating donors previously infected with SARS-CoV-2 during the first wave of the COVID-19 pandemic to understand how vaccination may reshape T cell populations formed after infection. 10 donors were investigated using single-cell RNA-sequencing consisting of a) 3 mild non-h...
ORGANISM(S): Homo sapiens 
2023-06-30 | E-MTAB-12716 | biostudies-arrayexpress
TranscriptomicsCai xin, lettuce and spinach gene expression atlas
Raw RNAseq data of hydroponically grown crops (cai xin, lettuce, and spinach) subjected under 31 different conditions. Comparative analysis of gene expression across species and stress conditions were carried out.
ORGANISM(S): Brassica rapa 
2024-04-30 | E-MTAB-14018 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of proteins interacting with Fbxw7 in T cells
To elucidate how gut microbiota (GM) downregulated Fbxw7, we treated CD4+ T cells with GM-lysates and pulled down Fbxw7 in the cell lysates. Then, the precipitated proteins were analyzed by mass spectrometry, and eight E3 ligases were revealed to interact with Fbxw7.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-16 | PXD057140 | Pride
Fbxw7  trim21  th17 cells  gut microbiota 
TranscriptomicsRNA-seq from sorted population of CD8 T cells (50 cells per sample) of human CD8 T memory stem cells (Tscm) subsets defined by surface expression of CD122 or CXCR3
Although it is recognised that CD8+ T memory stem cells (Tscm) are heterogeneous in phenotype and function, very few studies have sought to systematically examine these characteristics, particularly in human samples, as the population as a whole is rare and antigen-specific cells even more so. For e...
ORGANISM(S): Homo sapiens 
2022-03-10 | E-MTAB-10208 | biostudies-arrayexpress
ProteomicsMitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility
Immune elimination of chronic infection or cancer requires cytotoxic CD8 T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process and T cells subjected to chronic antigen exposure have compromised effector function despite high rates of...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD066950 | Pride
T cell Ctl Dahb Cd8 
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