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MetabolomicsFunctional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

Metabolic flexibility is key to survival and growth in all living organisms. In mammals, the pathways supporting cell proliferation in nutrient-limiting conditions have not been fully elucidated, although certain tumors display metabolic dependencies that can be targeted for therapy. He...

2026-02-02 | MTBLS13799 | MetaboLights
ProteomicsIdentification of novel SCF FBXW7 substrates in asynchronous and mitotic cells
FBXW7 loss-of-function has been implicated in chemoresistance against antimicrotubule drugs. FBXW7 is frequently mutated in human cancers and the identification of FBXW7 substrates, which could be involved in this phenotype, is a major task.
ORGANISM(S): Homo sapiens (Human) 
2022-12-02 | PXD035501 | Pride
Fbxw7 Ubiquitination Cell cycle 
GenomicsFBXW7
FBXW7
PRJNA783287 | ENA
ProteomicsFBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS
Myelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS performance, the molecular pathways that regulate these processes r...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-18 | PXD063570 | Pride
Primary cell culture Myelin Rat Mass spectrometry Fbxw7 Quantitative proteomics Oligodendrocytes 
ProteomicsCancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC
The FBXW7 tumour suppressor is commonly mutated, deleted or hypermethylated in a variety of cancer histologies. The tumour suppressive role of the FBXW7 protein has been ascribed to its ability to drive the ubiquitination and degradation of oncoproteins via its role as a substrate recognition subuni...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043904 | Pride
Cdc Fbxw7 Synthetic lethal 
ProteomicsTargeting mitochondrial translation overcomes multidrug resistance in FBXW7-deficient cells
FBXW7 is one of the most frequently mutated tumor suppressors, the deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatic analyses and genome-wide CRISPR screens, we here reveal that FBXW7 deficiency leads to multi-drug resistance (MDR), to a bigg...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-08 | PXD029981 | Pride
Tmt Q exactive Mescs 
ProteomicsMass spectrometry analysis of proteins interacting with Fbxw7 in T cells
To elucidate how gut microbiota (GM) downregulated Fbxw7, we treated CD4+ T cells with GM-lysates and pulled down Fbxw7 in the cell lysates. Then, the precipitated proteins were analyzed by mass spectrometry, and eight E3 ligases were revealed to interact with Fbxw7.
ORGANISM(S): Mus musculus (Mouse) 
2025-04-16 | PXD057140 | Pride
Fbxw7  trim21  th17 cells  gut microbiota 
GenomicsEffect of FBXW7 loss and concomitant FBXW7-KMT2D loss on mRNA levels
Effect of FBXW7 loss and concomitant FBXW7-KMT2D loss on mRNA levels
PRJNA623320 | ENA
TranscriptomicsTransriptional profiling upon heat shock and recovery in cells deficient for FBXW7 and their wild type counterpart.
FBXW7 modulates stress response by post-translational modification of HSF1 HSF1 orchestrates the heat-shock response upon exposure to heat stress and activates a transcriptional program vital for cancer cells. Genes positively regulated by HSF1 show increeased expression during heat shock while thei...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-57397 | biostudies-arrayexpress
GenomicsGenome-wide characterization of HSF1 binding in human WT and FBXW7 KO colon cancer cells under basal conditions and upon heat shock
FBXW7 modulates stress response by post-translational modification of HSF1 HSF1 orchestrates the heat-shock response upon exposure to heat stress and activates a transcriptional program vital for cancer cells. In this study we assayed for genome-wide localization of HSF1 enrichment in the HCT116 FBX...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-57398 | biostudies-arrayexpress
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