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ProteomicsDiscovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation
PKMYT1 has recently emerged as a compelling therapeutic target for precision cancer therapy due to its synthetic lethality with oncogenic alterations such as CCNE1 amplification and mutations in FBXW7 and PPP2R1A. Current small molecule PKMYT1 inhibitors face limitations, such as insufficient molecu...
ORGANISM(S): Homo sapiens (Human) 
2025-09-28 | PXD062889 | Pride
Protac Pkmyt1 Synthetic lethality Ai-generation 
UnknownIntensive Blood Pressure Lowering Improves Left Ventricular Hypertrophy in Older Patients with Hypertension: The STEP Trial.
Not available
S-EPMC10424814 | biostudies-literature
UnknownGenotype-Guided Dosing of Warfarin in Chinese Adults: A Multicenter Randomized Clinical Trial.
Not available
S-EPMC7439928 | biostudies-literature
ProteomicsProteomic Identification of the FgVps1 Interactome in Fusarium graminearum
This dataset contains the proteomic analysis of FgVps1, a dynamin-related GTPase, in Fusarium graminearum. GFP-tagged FgVps1 was expressed in the fungal hyphae, immunoprecipitated using GFP-Trap A beads, and associated proteins were identified by LC–MS/MS. The dataset provides a comprehensive view o...
ORGANISM(S): Fusarium Graminearum Ph-1 
2026-03-03 | PXD075137 |
UnknownEfficacy and Safety of Ginkgo Diterpene Lactone Meglumine in Acute Ischemic Stroke: A Randomized Clinical Trial.
Not available
S-EPMC10425831 | biostudies-literature
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