Cai Zhengnan Z - OmicsDI

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Metabolomics (2)
Proteomics (2)

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Alphavirus (2)
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Brassica oleracea var. oleracea (2)
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EFO:0001352 (2)
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Nostoc sp. PCC 7120 = FACHB-418 (2)
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Repository

MetaboLights (2)
pride (2)

Tissue

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Technology Type

Mass spectrometry (2)
Mass Spectrometry (2)
Shotgun proteomics (2)

Instrument Platform

Liquid Chromatography MS - positive - reverse phase (2)
Gas Chromatography MS - (1)
Gas Chromatography MS - positive (1)

Publication Date

2023 (2)
2022 (2)

CHEBI ID

CHEBI:18133 (2)
CHEBI:30838 (2)
CHEBI:15356 (2)
CHEBI:27266 (2)
CHEBI:16199 (2)
CHEBI:17148 (2)
CHEBI:42111 (2)
CHEBI:17050 (2)
CHEBI:15428 (2)
CHEBI:16958 (2)
CHEBI:32816 (2)
CHEBI:15978 (2)
CHEBI:22660 (2)
CHEBI:16449 (2)
CHEBI:25017 (2)
CHEBI:24898 (2)
CHEBI:16811 (2)
CHEBI:16737 (2)
CHEBI:27897 (2)
CHEBI:16113 (2)
CHEBI:28300 (2)
CHEBI:18257 (2)
CHEBI:15741 (2)
CHEBI:25094 (2)
CHEBI:17822 (2)
CHEBI:26271 (2)
CHEBI:18186 (2)
CHEBI:18012 (2)
CHEBI:30769 (2)
CHEBI:28044 (2)

Metabolite Name

Beta alanine (2)
Glycerol-3-phosphate (2)
Cholesterol (2)
Urea (2)
Hexose (2)
Malic acid (2)
Putrescine (2)
Lactic acid (2)
Pyruvic acid (2)
Citric acid (2)
Valine (2)
Tyrosine (2)
Serine (2)
Proline (2)
Phenylalanine (2)
Methionine (2)
Lysine (2)
Leucine (2)
Isoleucine (2)
Glycine (2)
Glutamine (2)
Cysteine (2)
Creatinine (2)
Alanine (2)
3-phosphoglycerate (2)
Taurine (2)
Fumaric acid (2)
Succinic acid (2)
Adenine (2)
Itaconic acid (2)

Lab affiliation

Head of Molecular Systems Biology Lab (MOSYS), Vice-Head Department Functional & Evolutionary Ecology, Head of Large Instrument Facility for Mass Spectrometry in Life Sciences, Chair of the Vienna Metabolomics Center (VIME) (1)
Molecular Systems Biology (MOSYS), Department of Function and Evolutionary Ecology, University of Vienna, Austria (1)

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Branched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights

Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights

Cancer-derived branched-chain ketoacids modulate macrophage polarization and metabolic reprogramming

This study aims to uncover the effects of cancer-derived branched-chain ketoacids on macrophage polarization and the underlying mechanism. We uncovered the global responses of branched-chain ketoacids-stimulated macrophages by proteomics analysis. Functional enrihment analysis indicated that these k...

ORGANISM(S): Mus musculus (Mouse)

2022-10-04 | PXD032100 | Pride

Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation, and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side effects. This study aimed to determine the preventive effects of norbergenin on LPS-induced inflammation and elucid...