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MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
ProteomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation, and blocking metabolic reprogramming
Inflammation is thought to be a key cause of many chronic diseases. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side effects. This study aimed to determine the preventive effects of norbergenin on LPS-induced inflammation and elucid...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-10 | PXD040202 | Pride
Norbergenin Inflammatory Murine Macrophages Q-exactive plus 
UnknownNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming.
Not available
S-EPMC10213229 | biostudies-literature
UnknownPotential antioxidative and anti-hyperuricemic components in Rodgersia podophylla A. Gray revealed by bio-affinity ultrafiltration with SOD and XOD.
Not available
S-EPMC10663331 | biostudies-literature
MetabolomicsPlant species richness promotes the decoupling of leaf and root defence traits while species-specific responses in physical and chemical defences are rare

The increased positive impact of plant diversity on ecosystem functioning over time is often attributed to the gradual accumulation of mutualists and dilution of antagonists in diverse plant communities. While increased plant diversity alters traits related to resource acquisition, it remains unc...

2025-02-13 | MTBLS8464 | MetaboLights
MetabolomicsMetabolomic profiling of colon tissue in loperamide-induced constipation mice treated with Rothia mucilaginosa

Untargeted metabolomics was performed on colon tissue from 26 C57BL/6 mice to investigate metabolic mechanisms underlying Rothia mucilaginosa-mediated constipation alleviation. Mice were divided into normal control (NC, n=8), loperamide-induced constipation model control (MC, n=8), and R. mucilag...

2026-04-27 | MTBLS13907 | MetaboLights
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