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TranscriptomicsCharacterization of the transcriptional response to hypoxia in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxic or normoxic conditions
To interrogate the hypoxia response pathways affected by the depletion of CAIX in BC cells, we performed gene expression profiling using SurePrint G3 Human Gene Expression 60K microarrays in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxi...
ORGANISM(S): Homo sapiens 
2018-01-01 | E-MTAB-5512 | biostudies-arrayexpress
TranscriptomicsNeurological defects in CAIX knockout mice
To further identify transcriptomic responses to CAIX deficiency in the brain, genome-wide cDNA microarray analyses were performed. Thirty-one and 37 genes were up- and down-regulated in the brain of Car9-/- mice as compared to wild-type mice. Functional annotation revealed that genes with increased ...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-24051 | biostudies-arrayexpress
ProteomicsInhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells
Experiments were performed assessing whether targeting the pH regulatory proteins (CAIX, NHE1 and V-ATPase) that permit cancer cells to adapt to hypoxic conditions could produce an effective therapeutic response in breast cancer, using both 2D and 3D culture models. CAIX inhibitors were shown to com...
ORGANISM(S): Homo sapiens (Human) 
2017-05-02 | PXD005706 | Pride
Irradiation Breast Hypoxic Caix 
OtherGenome-wide synthetic lethal screen unveils novel CAIX – NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
Hypoxia is an important clinicopathological feature of solid tumours that limits response to therapy. Carbonic Anhydrase IX (CAIX) is a hypoxia-induced, pH regulator that has emerged as a viable therapeutic target. Targeting CAIX has demonstrated promise in difficult to treat preclinical models of b...
ORGANISM(S): Homo sapiens 
2021-08-28 | GSE167481 | GEO
GenomicsGenome-wide synthetic lethal screen unveils novel CAIX – NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
Genome-wide synthetic lethal screen unveils novel CAIX – NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
PRJNA704708 | ENA
TranscriptomicsNeurological defects in CAIX knockout mice
To further identify transcriptomic responses to CAIX deficiency in the brain, genome-wide cDNA microarray analyses were performed. Thirty-one and 37 genes were up- and down-regulated in the brain of Car9-/- mice as compared to wild-type mice. Functional annotation revealed that genes with increased ...
ORGANISM(S): Mus musculus 
2011-12-31 | GSE24051 | GEO
UnknownTargeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma.
Not available
S-EPMC6827823 | biostudies-literature
UnknownCAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models.
Not available
S-EPMC6906415 | biostudies-literature
GenomicsDifferential gene expression profiles associated with CAIX expression in patients with ER negative breast cancer
Differential gene expression profiles associated with CAIX expression in patients with ER negative breast cancer
PRJEB54720 | ENA
UnknownUnique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology.
Not available
S-EPMC2835754 | biostudies-literature
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