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TranscriptomicsGenome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae
In Saccharomyces cerevisiae, the Ca2+/calmodulin-dependent protein phosphatase, calcineurin, is activated by specific environmental conditions, including exposure to Ca2+ and Na+, and induces gene expression by regulating the Crz1p/Tcn1p transcription factor. We used DNA microarrays to perform a com...
ORGANISM(S): Saccharomyces cerevisiae 
2005-10-15 | E-GEOD-3456 | biostudies-arrayexpress
TranscriptomicsMouse heart tissue: wild-type vs. aMHC-Calcineurin transgenic (CnTg)
Cardiac profiling of miR expression levels in a transgenic mouse model of heart failure (MHC-CnA) to identify miRs that are co-regulated with the development of calcineurin-induced heart failure. Two-condition experiment: WT vs CnTg. Biological replicates: one array was performed on 3 pooled samples...
ORGANISM(S): Mus musculus 
2011-11-02 | E-GEOD-25006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary rat hippocampal culture cells overexpressing an activated form of calcineurin
Micorarray analysis was performed on RNA samples from hippocampal cultures infected with either Ad-aCaN or Ad-LacZ or uninfected. Each sample was applied to its own GeneChip (Rat RG-U34A; n=7-9 chips/group). Chips were then processed and scanned using Agilent Affymetrix GeneArray Scanner. MAS5 was u...
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1978 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast treated with calcium, sodium
In Saccharomyces cerevisiae, the Ca2+/calmodulin-dependent protein phosphatase, calcineurin, is activated by specific environmental conditions, including exposure to Ca2+ and Na+, and induces gene expression by regulating the Crz1p/Tcn1p transcription factor. We used DNA microarrays to perform a com...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-23 | E-SMDB-1427 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast treated with calcium, sodium
In Saccharomyces cerevisiae, the Ca2+/calmodulin-dependent protein phosphatase, calcineurin, is activated by specific environmental conditions, including exposure to Ca2+ and Na+, and induces gene expression by regulating the Crz1p/Tcn1p transcription factor. We used DNA microarrays to perform a com...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-30 | E-SMDB-15 | biostudies-arrayexpress
TranscriptomicsAAV2-GFP-Calcineurin anchoring disruptor microarray
We have analyzed how interaction of calcineurin with perinuclear signalosome AKAP6 affects the expression profile of transcription factors involved in cAMP/calcium signaling. We have found that calcineurin interacts with AKAP6 in calcium-dependent manner and by using anchoring disruptors, we demonst...
ORGANISM(S): Rattus norvegicus 
2024-12-12 | E-MTAB-14614 | biostudies-arrayexpress
TranscriptomicsCalcineurin/NFAT signaling inhibits myeloid hematopoiesis in mice.
Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signaling can also mediate granulocyte and DC activation, but it is unknown whether NFAT influences their development from progenitors. Here w...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-29094 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression regulated by calcineurin-NFAT signaling in mouse embryonic stem cells
Self-renewal and pluripotency are hallmarks of embryonic stem cells (ESCs). However, signaling pathways triggering their transition from self-renewal to differentiation are not well defined. Here, we report that the calcineurin-NFAT signaling pathway is both necessary and sufficient to switch ESCs f...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-21378 | biostudies-arrayexpress
GenomicsFunctions of calcineurin-NFAT signaling pathway in human embryonic stem cells
Functions of calcineurin-NFAT signaling pathway in human embryonic stem cells
PRJNA650305 | ENA
TranscriptomicsThe Calcineurin-NFAT-Angiopoietin 2 signaling axis in lung endothelium is critical for the establishment of lung metastases
The pre-metastatic niche is a pre-determined site of metastases, awaiting the influx of tumor cells. Here we demonstrate that the calcineurin-NFAT pathway is activated specifically in lung endothelium prior to the detection of tumor cells that preferentially metastasize to the lung. We previously sh...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-48841 | biostudies-arrayexpress
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