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ProteomicsSIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination o...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-05 | PXD005896 | Pride
Protein acylation Insulin secretion Leucine metabolism Sirt4 
ProteomicsRemodelling of the acetylproteome by SIRT3 manipulation fails to affect insulin secretion or beta-cell metabolism in the absence of over nutrition
From Peterson et. al. 2018: SIRT3 is an NAD+-dependent mitochondrial protein deacetylase purported to influence metabolism through post-translational modification of metabolic enzymes. Fuel-stimulated insulin secretion, which involves mitochondrial metabolism, could be susceptible to SIRT3-mediated...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-06-21 | PXD009509 | Pride
Pancreas Protein acetylation Beta cells Sirt3 
UnknownLET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition.
Not available
S-EPMC7756138 | biostudies-literature
ProteomicsC4PR_LIV Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer
Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is essential to advance understanding of phosphorylation-mediated signaling events. However, development of novel instrumentation requires that methods for MS data acquisition and its interrogation be evaluated an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-31 | MSV000085203 | MassIVE
UnknownOlder molecular brain age in severe mental illness.
Not available
S-EPMC7785531 | biostudies-literature
UnknownThe benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.
Not available
S-EPMC3386495 | biostudies-literature
UnknownCD8<sup>+</sup> T cells exacerbate AD-like symptoms in mouse model of amyloidosis.
Not available
S-EPMC11409913 | biostudies-literature
UnknownRare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation.
Not available
S-EPMC6731366 | biostudies-literature
UnknownThe effect of artificial selection on phenotypic plasticity in maize.
Not available
S-EPMC5677005 | biostudies-literature
UnknownMaize Genomes to Fields: 2014 and 2015 field season genotype, phenotype, environment, and inbred ear image datasets.
Not available
S-EPMC6038255 | biostudies-literature
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