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ProteomicsProteomic analysis of extracellular matrix remodeling during zebrafish heart regeneration
Adult zebrafish, in contrast to mammals, are able to regenerate their hearts in response to injury or experimental amputation. Our understanding of the cellular and molecular bases that underlie this process, although fragmentary, has increased significantly over the last years. However, the role of...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-08-26 | PXD010092 | Pride
Extracellular matrix  heart regeneration 
ProteomicsPresence of ceramidase activity in electronegative LDL
Electronegative LDL (LDL(-)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them, LDL(-) has increased content of bioactive lipid mediators, such as lysophosphatidylcholine (LPC), non-esterified fatty acids (NEFA), ceramide (Cer), and sphingosine (Sph), w...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD036168 | Pride
Electronegative ldl  ceramide  sphingosine  ceramidase  sphingomyelinase 
ProteomicsCirculating SOD2 is a Response Biomarker for Neoadjuvant Therapy in Breast Cancer
There is a great need of non-invasive tools that inform of an early molecular response to cancer therapeutic treatment. Here, we have tested the hypothesis that proteolytically resistant proteins could be candidate circulating tumor biomarkers for cancer therapy. Proteins resistant to proteolysis ar...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD032359 | Pride
Proteolysis-resistant proteins Sod2 Biomarker 
ProteomicsThe Yin and Yang of GDF15: a secreted biomarker of eribulin response in breast cancer cells, yet required for survival of drug tolerant persister (DTP) cells
Drug tolerant persister (DTP) cells enter into a reversible slow-cycling state after cancer drug treatment. These cells are the living proof of response to a drug, and an interesting experimental subject for biomarker discovery. Here, we performed proteomic characterization of the breast cancer (BC)...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD034037 | Pride
Eribulin Drug tolerance Growth differentiation factor (gdf15) Secretome. Drug tolerant persister (dtp) Breast cancer (bc) 
ProteomicsSecretome analysis of human A549 Lung cancer cells harboring LKB1 mutations.
STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation. Elucidating the contribution of somatic mutations to cancer is essential for personalized medicine. STK11 (LKB1) tumor suppressor appears to be inactivated in human cancer, however, somatic missense mutati...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018041 | Pride
Human  lung cancer  lkb1  lc-msms  secretome 
ProteomicsBRAF activation by metabolic stress promotes glycolysis and survival, sensitizing NRASQ61 mutated melanomas to targeted therapy.
NRAS-mutated melanoma lacks an approved first-line treatment. Metabolic reprogramming is considered a novel target to control cancer; however, it is mostly unknow how the NRAS oncogene contributes to this cancer hallmark. Here, we show that NRASQ61-mutated melanomas harbor specific metabolic alterat...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD028297 | Pride
Melanoma  braf  nras mutation  metabolic stress  pfkfb2 
TranscriptomicsExpression profile of A459 cells upon LKB1 expression
The purpose of the experiment is to study the expression profiles variations upon the expression of the wild type isoform of LKB1 (STK11) in human lung carcinoma A459 cells. These cells are KRAS mutated and null for STK11. Cells were previously infected with the lentiviral construct pLenti-rtTA2-IRE...
ORGANISM(S): Homo sapiens 
2020-06-11 | E-MTAB-8863 | biostudies-arrayexpress
GenomicsNuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer
Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/?-catenin signaling. Dickkopf (DKK)-1 is an extracellular inhibitor of Wnt/?-catenin signaling that also has undefined ?-catenin-independent actions. Here we report for the first time that a proportion of DKK...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-31170 | biostudies-arrayexpress
ProteomicsA mouse brain-based multi-omics integrative approach reveals potential blood biomarkers for ischemic stroke
Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures of acute ischemic stroke is still of primary interest for a real translational research on stroke diagnosis, prognosis and treatment. Integration of data from...
ORGANISM(S): Mus Musculus 
2020-09-07 | PXD017280 | panorama
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. Jurkat Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083966 | MassIVE
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