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TranscriptomicsSynthetic Lethal Interaction Between Oncogenic KRAS Dependency and Suppression of STK33 in Human Cancer Cells
Many human oncogenes are challenging therapeutic targets. An alternative to direct targeting of oncogenes is to perform â??synthetic lethalityâ?? screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify...
ORGANISM(S): Homo sapiens 
2009-06-24 | E-GEOD-15151 | biostudies-arrayexpress
TranscriptomicsRescue of KRAS suppression in HCT116 colon cancer cell line
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically ex...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-55942 | biostudies-arrayexpress
TranscriptomicsKRAS and YAP1 converge to regulate EMT and tumor survival
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically ex...
ORGANISM(S): Mus musculus 
2014-07-27 | E-GEOD-56175 | biostudies-arrayexpress
ProteomicsMutant KRAS-associated proteome is mainly controled by exogenous factors
KRAS signaling has been extensively studied, yet the clarification between KRAS-autonomous and non-autonomous mechanisms are still less explored. Understanding how KRAS signaling and effects are affected by exogenous stimuli can provide valuable insights not only to understand resistance mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD030551 | Pride
Mutant kras  colorectal cancer  cancer associated-fibroblasts  proteomic analysis 
ProteomicsA Systems Mechanism for KRAS Mutant Allele Specific Responses to Targeted Therapy
Cancer treatment decisions are increasingly guided by which specific genes are mutated within each patient’s tumor. For example, agents inhibiting the epidermal growth factor receptor (EGFR) benefit many colorectal cancer (CRC) patients, with the general exception of those whose tumor includes a KR...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD014755 | Pride
Thus resolving a problem in cancer personalized medicine. Systems approaches reveal why cancer patients with one specific kras mutation respond to egfr inhibitors 
GenomicsTGFbeta treatment drives iKPC PDAC cells to bypass KRAS* dependency
TGFbeta treatment drives iKPC PDAC cells to bypass KRAS* dependency
PRJNA627427 | ENA
ProteomicsReconstructing targetable pathways in lung cancer by integrating diverse omics data
We profile transcriptome, proteome and phosphoproteome in a panel of non-small cell lung cancer (NSCLC) cell lines in order to reconstruct targetable networks associated with KRAS dependency. We develop a two-step bioinformatics strategy addressing the challenge of integrating these disparate datase...
ORGANISM(S): Homo sapiens (Human) 
2014-06-24 | PXD000439 | Pride
Lung cancer Kras Cancer Cancer by kras dependency Human Proteome Phosphoproteome 
UnknownTumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer.
Not available
S-EPMC7334087 | biostudies-literature
ProteomicsLKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
KRAS-mutant lung cancers frequently have inactivating mutations in LKB1, which enhances tumor growth, metastasis, and immune evasion. This study shows that LKB1 suppresses JNK stress signaling, and its loss in KRAS-mutant cells leads to JNK hyperactivation and apoptotic rewiring, making them sensiti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-03-06 | MSV000097246 | MassIVE
ProteomicsMYC-dependent kinome in pancreatic cancer
We recently established the ERK-dependent transcriptome and phosphoproteome in KRAS-mutant pancreatic ductal adenocarcinoma (PDAC). Of 1,718 ERK-dependent genes, 143 encode transcription factors. Of 2,123 ERK-dependent phosphoproteins, 98 are transcription factors. Despite this complexity, we observ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-15 | PXD061413 | Pride
Mib-ms Myc Pancreatic cancer Kinome 
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