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TranscriptomicsTranscriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome
RNA-seq analysis of an in vivo murine model of vulvovaginal candidiasis Murine vaginas were infected with Candida albicans and harvested for RNA-seq analysis 3 days post-infection
ORGANISM(S): Mus musculus 
2015-04-11 | E-GEOD-67688 | biostudies-arrayexpress
TranscriptomicsElucidating Host-Pathogen Interaction in Acute Systemic Candidiasis in a Mouse Model Using Genomic Approach
Candida species is a common fungus that had evolved as both commensal and opportunistic pathogen in humans. The rise in human morbidity and mortality caused by Candida species sparked an alarming concern. However, the thin line between commensalism and infection as well as the analysis of Candida h...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-16339 | biostudies-arrayexpress
TranscriptomicsBlood Gene Expression Signatures Predict Invasive Candidiasis
Focusing on host response to infection, we utilized a murine model to develop a  blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from S. aureus bacteremia.  Validation of the signature was achieved in an independent cohort of mice. BALB/...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-20524 | biostudies-arrayexpress
TranscriptomicsFunctional genomics identifies type I interferon pathway as central for host defense against Candida albicans
Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. By integrating transcriptional analysis and functional genomics we identified Candida-specific host defense mechanisms in humans. Candida indu...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42630 | biostudies-arrayexpress
GenomicsThe Mechanism of Gene Regulation in Recurrent Vulvovaginal Candidiasis (RVVC Group)
The Mechanism of Gene Regulation in Recurrent Vulvovaginal Candidiasis (RVVC Group)
PRJNA1398073 | ENA
ProteomicsProtein microarray-based autoantibody screening in 51 APS1 patients and 21 healthy controls
Autoimmune polyendocrine syndrome type 1 (APS1) is a monogenic disorder that features multiple autoimmune disease manifestations. It is caused by mutations in the Autoimmune regulator (AIRE) gene, which promote thymic display of thousands of peripheral tissue antigens in a process critical for estab...
ORGANISM(S): Homo sapiens 
2019-06-27 | E-MTAB-8097 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of Candida albicans to endothelial cells
Candida albicans is exposed to a different host environment during different site of infection. Thus, different virulence factors may be active during differenttypes of infection. However,little is known about the C. albicans genes that are required for the initiation and maintenance of candidiasis....
ORGANISM(S): Candida albicans 
2010-06-30 | E-GEOD-5344 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of Candida albicans to oral epithelial cells
Candida albicans is exposed to a different host environment during oropharyngeal candidiasis (OPC) compared to hematogenously disseminated candidiasis. Thus, different virulence factors may be active during these two types of infection. However,little is known about the C. albicans genes that are ...
ORGANISM(S): Candida albicans 
2010-06-24 | E-GEOD-5340 | biostudies-arrayexpress
GenomicsTongue RNA expression after oropharyngeal candidiasis in mice deficient in CCL28
Tongue RNA expression after oropharyngeal candidiasis in mice deficient in CCL28
PRJNA694936 | ENA
TranscriptomicsAntibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
IL17A KO mouse tongues after 2 days of C. albicans infection were profiled and compared to WT. In addition, tongues from animals infected for 2 days with C. albicans and then treated with anti-IL17A antibody, anti-IL17F antibody, anti-IL17A and anti-IL17F antibodies together, or isotypes controls ...
ORGANISM(S): Mus musculus 
2015-12-21 | E-MTAB-4167 | biostudies-arrayexpress
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