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ProteomicsA structural model of the human mSWI/SNF (BAF) complex bound to the nucleosome informs disease mechanisms
Mammalian SWI/SNF complexes are multi-component ATP-dependent chromatin-remodeling complexes that regulate genomic architecture. Here we present the first structural model of the human canonical BAF chromatin-remodeling complex bound to a nucleosome generated using cryo-EM, cross-linking mass spectr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-10 | PXD020992 | Pride
Homology model Cryo-em Atp-dependent chromatin remodeling Nucleosome acidic patch Yeast swi/snf Mammalian swi/snf Canonical baf complex Human disease Mutations 
ProteomicsA non-canonical BRD9-containing BAF chromatin remodeling complex regulates naïve pluripotency in mouse embryonic stem cells
The mammalian BRG1-associated factors (BAF) complex is a multi-subunit chromatin remodeling complex that is an important component of the embryonic stem cell (ESC) transcriptional regulatory network. However, the role of individual subunits in BAF complex targeting and function needs to be elucidate...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010670 | Pride
Baf Chromatin remodeling 
ProteomicsMudPIT analyses of the proteins co-purified with components of the LSD1 (KDM1A) transcriptional repressor complex and the non-canonical BAF complex, immuno-precipitated from MKL-1 and WaGa MCC cell lines
Protein Complexes Purification: Immunoprecipitations were performed with antibodies to LSD1 (2139; Cell signaling technology), INSM1 Mouse (SC-271408, Santa Cruz Biotechnology), RCOR2 (23969-1-AP; Proteintech Group), BRD9 (61537; Active Motif Rabbit), and normal Rabbit IgG (2729; Cell signaling tech...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-25 | MSV000083364 | MassIVE
ProteomicsA non-canonical SWI/SNF complex underlies synthetic lethality in cancers driven by BAF complex perturbation
Mammalian SWI/SNF chromatin remodeling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF, and a newly characterized non-canonical complex, ncBAF. However, their complex-specific targeting on chromatin, functions and roles in disease remain largely unknown. Here, we...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD011103 | Pride
Brd7 Mswi/snf Chromatin remodeling Brd9 Baf Dpf2 
GenomicsSpliceosomal disruption of the non-canonical BAF complex in cancer
Spliceosomal disruption of the non-canonical BAF complex in cancer
PRJNA513262 | ENA
GenomicsCell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity
PRJNA1438638 | ENA
UnknownSpliceosomal disruption of the non-canonical BAF complex in cancer.
Not available
S-EPMC6858563 | biostudies-literature
GenomicsA non-canonical BRD9-containing BAF chromatin remodeling complex regulates naïve pluripotency in mouse embryonic stem cells
A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naïve pluripotency in mouse embryonic stem cells
PRJNA436371 | ENA
GenomicsBRD9 CFT8634 ATAC Seq (primary cells)-Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex
BRD9 CFT8634 ATAC Seq (primary cells)-Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex
PRJNA1238771 | ENA
GenomicsBAF60A KO RNA seq (primary cells)-Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex
BAF60A KO RNA seq (primary cells)-Highly discriminative globin gene activation by the non-canonical BAF chromatin remodeling complex
PRJNA1365854 | ENA
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