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ProteomicsBRD9 regulates leukemic cell survival via STAT5 pathway inhibition
Leukemia is characterized by genetic and epigenetic mutations resulting in selection of cancer stem cells, which are unable to differentiate. While genetic alterations are difficult to target, the epigenome is intrinsically dynamic and readily offers new therapeutic strategies. Thus, identifying can...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013245 | Pride
Lc-msms Stat5 Leukemia Brd9 
ProteomicsInteractome of a TurboID-tagged BRD9 in the presence or absence of IFN-a2
BRD9 was identified in a genome-wide screen for genes regulating the response to interferon (IFN) in a A549 based reporter cell line. Subsequent experiments determined an involvement of BRD9 in the transcriptional regulation of Interferon-stimulated genes (ISGs) expression following stimulation with...
ORGANISM(S): Homo sapiens (Human) 
2021-08-17 | PXD026926 | Pride
Brd9 Proximity labeling A549 Brd9-turboid Ifn-signalling Stat2 Turboid 
ProteomicsA non-canonical BRD9-containing BAF chromatin remodeling complex regulates naïve pluripotency in mouse embryonic stem cells
The mammalian BRG1-associated factors (BAF) complex is a multi-subunit chromatin remodeling complex that is an important component of the embryonic stem cell (ESC) transcriptional regulatory network. However, the role of individual subunits in BAF complex targeting and function needs to be elucidate...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010670 | Pride
Baf Chromatin remodeling 
ProteomicsBRD9 degraders CAN-25-5405-ETR1
BRD9 degraders unleash GBAFCHromatin Remodeling Activity in Synovial Sarcoma
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD079388 | Pride
Brd9 degraders gbaf chromatin 
GenomicsGenome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown
Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown
PRJNA531322 | ENA
ProteomicsSelective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept
Prospective discovery of molecular glues degraders for a specific therapeutic target protein of interest is an emerging strategy in drug discovery. Modification of pre-existing ligands with fragments that can alter the protein surface can lead to the creation of novel compounds (‘’targeted glues’’)...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD062355 | Pride
Tmt Hek293 ip-ms 
ProteomicsBRD9 functions as a methylarginine reader to regulate AKT-EZH2 signaling
Arginine methylation is a common posttranslational modification that is catalyzed by a family of protein arginine methyltransferases. Recognition of methylarginine marks by effector proteins (“readers”) is a critical link between arginine methylation and various cellular processes. We recently ident...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD058540 | Pride
Methylarginine Akt-ezh2 signaling Brd9 
GenomicsFunction of BRD9 during osteoclastogenesis [RNA-seq]
Function of BRD9 during osteoclastogenesis [RNA-seq]
PRJNA918653 | ENA
GenomicsFunction of BRD9 during osteoclastogenesis [ChIP-Seq]
Function of BRD9 during osteoclastogenesis [ChIP-Seq]
PRJNA923673 | ENA
GenomicsFunction of BRD9 during osteoclastogenesis [ATAC-seq]
Function of BRD9 during osteoclastogenesis [ATAC-seq]
PRJNA918657 | ENA
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