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MetabolomicsNon-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Calorie restriction (CR) extends lifespan and healthspan in diverse species. However, comparing ad libitum (AL) and CR-fed mice is challenging due to their significantly different feeding patterns. CR-fed mice consume their daily meal in approximately 2 hours, subjecting themselves to a prol...

2025-07-07 | MTBLS10795 | MetaboLights
TranscriptomicsLS001A: Aging/Early Degeneration Of The Intervertebral Disc Involves Downregulation Of Canonical Wnt Signaling and Caveolin-1 expression
Objective: Aging and early degeneration of the intervertebral disc (IVD) involves the substition of notochordal cells (NCs) in the nucleus pulposus (NP) by chondrocyte-like cells (CLCs). This study investigated the gene expression profiles involved in this process using NP tissue from both non-chond...
ORGANISM(S): Canis lupus familiaris 
2013-01-31 | E-GEOD-35717 | biostudies-arrayexpress
TranscriptomicsDissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive ...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-54611 | biostudies-arrayexpress
ModelsTrares2022 - Crosstalk between the canonical and non-canonical NF-kB pathways, Petri net
No description
2022-07-22 | MODEL2207210003 | BioModels
TranscriptomicsThe transcriptional response to Norrin/Fz4 signaling
Using mice with targeted gene mutations, we identify (1) distinct roles for different canonical Wnt signaling components in central nervous system (CNS) vascular development and in the specification of the blood-brain and blood-retina barriers (BBB and BRB) and (2) differential sensitivities of the ...
ORGANISM(S): Mus musculus 
2014-06-05 | E-GEOD-56461 | biostudies-arrayexpress
GenomicsTranscriptomics Unveil Canonical and Non-Canonical Heat Shock-Induced Pathways in Human Cell Lines
Transcriptomics Unveil Canonical and Non-Canonical Heat Shock-Induced Pathways in Human Cell Lines
PRJNA1204088 | ENA
TranscriptomicsA supporting environment for hematopoietic stem/progenitor cells is maintained by canonical Wnt signaling
Considerable information has accumulated about components of bone marrow that regulate survival, self-renewal and differentiation of hematopoietic cells. We have now studied Wnt signaling in that context, assessing influences on human and murine hematopoiesis. Microarray, PCR and staining experime...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-30791 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of canonical and non-canonical NF-κB signaling pathways in Hodgkin’s lymphoma
Malignant Hodgkin's lymphoma (HL) cells are characterized by constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We depleted subunit combinations corresponding to either canonical (p50/RelA) or non-canonical (p52/RelB) dimers in the HL cell line L-1236 an...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-64232 | biostudies-arrayexpress
TranscriptomicsThe dynamics of E1A in regulating networks and canonical pathways in quiescent cells
Adenoviruses force quiescent cells to re-enter the cell cycle to replicate their DNA, and for the most part, this is accomplished after they express the E1A protein immediately after infection. In this context, E1A is believed to inactivate cellular proteins (e.g., p130) that are known to be involve...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-28420 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis reveals the involvement of canonical Wnt signaling in zebrafish gonad differentiation
Zebrafish males undergo a juvenile ovary to testis type gonadal transformation process. To understand how juvenile ovary-to-testis transformation in zebrafish is genetically regulated, we compared the transcriptomes of juvenile ovary (JO) and juvenile ovotestis (JOT) samples at 35 dpf using the Gona...
ORGANISM(S): Danio rerio 
2013-12-27 | E-MEXP-3879 | biostudies-arrayexpress
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