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ProteomicsQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks
The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population. We used Stable Isotope Labelling of Amino acids in Culture (S...
ORGANISM(S): Mus musculus (Mouse) 
2014-10-03 | PXD001076 | Pride
Silac Pkd2 Phosphoproteomics Lymphocytes 
OtherQuantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks.
Data from ProteomeXchange, PXD ID: PXD001076. Experiment: JG-N2, file: JG-N2-12.mzml. Published as part of Mol Cell Proteomics. 2014 Sep 29 . From the Abstract: {{i}} ... We used Stable Isotope of Amino acids in Culture (SILAC) combined with phosphopeptide enrichment and quantitative mass-spectrome...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320004050 | GPMDB
Resource Reanalysis 
TranscriptomicsRole of PKD2 in TCR-induced transcriptional reprogramming of naïve T cells
Comparison of transcriptional profile of TCR stimulated P14-TCR wild-type and P14-PKD2 null murine lymph node cells Lymph node cells from 3 biological replicates (3 wild-type and 3 PKD2 null mice) were isolated and left unstimulated or stimulated for 4 hours with antigenic peptide (gp33-41) prior to...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33942 | biostudies-arrayexpress
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres
This SuperSeries is composed of the following subset Series: GSE32310: Transcriptome analysis of mediator Med20 mutant and dcr1 mutant in S.pombe GSE35524: Mediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq] Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35527 | biostudies-arrayexpress
UnknownGenomic alterations that contribute to the development of isolated and non-isolated congenital diaphragmatic hernia.
Not available
S-EPMC3227222 | biostudies-literature
ProteomicsPhosphoproteomic analyses of IL-2 signaling reveals integrated JAK-dependent and independent phosphorylation networks that drive cytotoxic T cell fate
High-resolution mass spectrometry analysis of Interleukin 2 (IL-2) and Janus kinase (JAK) controlled protein phosphorylations in cytotoxic T lymphocytes (CTL) revealed JAKs coupled IL-2 receptors to diverse and complex serine/threonine kinase-substrate networks. These involved intricate, co-ordinate...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-25 | PXD004645 | Pride
Lck/fyn Lymphocytes. Silac Jak1 Il-2 Jak3 Phosphoproteomics 
ProteomicsInterleukin-2 shapes the cytotoxic T cell proteome and immune-environment sensing
Interleukin-2 (IL-2) and Janus kinases (JAKs) regulate transcriptional programs and protein synthesis to control the differentiation of effector CD8+ cytotoxic T cells (CTL). Using high-resolution mass spectrometry, we have generated an in-depth characterisation of how IL-2 and JAKs configure the CT...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-17 | PXD008112 | Pride
Proteomics Jak1 Il-2 Interleukin-2 Jak3 Lymphocytes 
ProteomicsMass Spectrometry identifies temporal changes and hallmarks of Delayed Recovery in the COVID19 Neutrophil proteomes
High-resolution mass spectrometry and the parallel quantitative evaluation of thousands of proteins has been used to characterise the proteomes of peripheral blood neutrophils from >200 individuals. This work has comprehensively mapped neutrophil molecular changes associated with mild versus severe ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036082 | Pride
Proteomics Long covid Dia Interferon Mass spectrometry Human Covid19 Neutrophil 
ProteomicsMass Spectrometry identifies temporal changes and hallmarks of Delayed Recovery in the COVID19 Neutrophil proteomes part2
Mass Spectrometry identifies temporal changes and hallmarks of Delayed Recovery in the COVID19 Neutrophil proteomes MTD project_description High-resolution mass spectrometry and the parallel quantitative evaluation of thousands of proteins has been used to characterise the proteomes of peripheral bl...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036089 | Pride
Proteomics Long covid Dia Interferon Mass spectrometry Human Covid19 Neutrophil 
UnknownProtein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.
Not available
S-EPMC3462612 | biostudies-literature
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