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TranscriptomicsRole of PKD2 in TCR-induced transcriptional reprogramming of naïve T cells
Comparison of transcriptional profile of TCR stimulated P14-TCR wild-type and P14-PKD2 null murine lymph node cells Lymph node cells from 3 biological replicates (3 wild-type and 3 PKD2 null mice) were isolated and left unstimulated or stimulated for 4 hours with antigenic peptide (gp33-41) prior to...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33942 | biostudies-arrayexpress
TranscriptomicsCyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways
Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been made in understanding the pathologic mechanism of the disease, the precise orchestration of t...
ORGANISM(S): Rattus norvegicus 
2010-01-31 | E-GEOD-19460 | biostudies-arrayexpress
ProteomicsPKD2-like proteins target Chlamydomonas PKD2 to distinct subciliary regions
Many motile and sensory functions of cilia and flagella depend on the precise localization of transmembrane proteins within the ciliary membrane. Rather than being uniformly distributed, these proteins are often targeted to specific subciliary regions along the length or circumference of cilia. He...
ORGANISM(S): Chlamydomonas reinhardtii 
2026-10-02 | PXD071255 | Pride
Polycystin-2 Pkd Mastigonemes Cilia Trp channel Flagella 
ProteomicsIdentification of human PKD2 interaction partners from cytosolic protein fractions of HeLa cells by affinity enrichment cross-linking/MS
We investigated the interaction network of human PKD2 in the cytosol as well as in Golgi-enriched subcellular protein fractions, using an affinity enrichment strategy combined with chemical cross-linking/mass spectrometry (MS). Analysis of the subproteomes revealed the presence of distinct proteins ...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD003909 | Pride
Human Pkd2 Cross-linking/ms Affinity enrichment Orbitrap fusion 
ProteomicsIdentification of human PKD2 interaction partners from Golgi-enriched protein fractions of HeLa cells by affinity enrichment cross-linking/MS
We investigated the interaction network of human PKD2 in the cytosol as well as in Golgi-enriched subcellular protein fractions, using an affinity enrichment strategy combined with chemical cross-linking/mass spectrometry (MS). Analysis of the subproteomes revealed the presence of distinct proteins ...
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD003913 | Pride
Human Pkd2 Hela cells Cross-linking/ms Affinity enrichment Golgi apparatus Orbitrap fusion 
TranscriptomicsNext Generation Sequencing of PKD2 mutant mice kidneys
This Study sought to understand the differential gene expression profile of Pkd2 mutant mice kidneys in the setting of miR-21 deletion 4 Wild type mice, 3 Pkd2 Knockout mice and 3 Pkd2-miR-21 knockout mice were analyzed
ORGANISM(S): Mus musculus 
2016-01-05 | E-GEOD-69556 | biostudies-arrayexpress
ProteomicsRegulation of the PKD2 channel function and associated disease phenotypes by RASSF4
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic genetic disorders, caused by mutations in receptor PKD1 or ion channel PKD2, and is characterized by progressive renal cyst development with additional hepatic and extrarenal manifestations. As effective treatme...
ORGANISM(S): Homo Sapiens 
2026-02-13 | PXD074819 |
TranscriptomicsGenotyping of PKD2 Arg803* in Taiwan ADPKD Cohort
PKD2 Arg803* is the most common mutation in Taiwan ADPKD Cohort. Genotyping of 96 PKD2 Arg803* individuals was performed in Axiom Genome-Wide TWB 2.0 Array Plate to study the existence of founder mutation in Taiwan
ORGANISM(S): Homo sapiens 
2022-06-07 | E-MTAB-11846 | biostudies-arrayexpress
GenomicsPkd2-dependent transcriptome profile in a newly estabilshed mouse Pkd2 knockout cell line
Pkd2-dependent transcriptome profile in a newly estabilshed mouse Pkd2 knockout cell line
PRJNA720116 | ENA
GenomicsPkd1 and Pkd2 mRNA cis-inhibition drives polycystic kidney disease progression [Pkd2]
Pkd1 and Pkd2 mRNA cis-inhibition drives polycystic kidney disease progression [Pkd2]
PRJNA805547 | ENA
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