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ProteomicsProteome profiling of whole plasma and plasma-derived extracellular vesicles facilitates the detection of tissue biomarkers in the non-obese diabetic (NOD) mouse
Using plasma samples collected from pre-diabetic non-obese diabetic (NOD) mice (an experimental model of T1D) we performed parallel analysis of whole plasma samples and plasma-derived extracellular vesicle (EV) fractions using mass spectrometry (MS). Whole plasma samples were depleted of abundant pr...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-20 | PXD033867 | Pride
Biomarkers  extracellular vesicles  exosomes  mass spectrometry  mouse  non-obese diabetic (nod) mouse  plasma  type 1 diabetes 
ProteomicsLabel-free and targeted mass tandem (TMT-labelled) global proteomic analyses on mucus from the stomach, small and large intestine of a domestic and laboratory dogs
Gastrointestinal (GI) mucus is continuously secreted and lines the entire length of the GI tract. Essential for health, it keeps the noxious luminal content away from the epithelium and propels forward the digesta. The aim of our study was to characterize the composition and structures of mucus thro...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2022-03-07 | PXD029356 | Pride
Canine Gastrointestinal Mucus Composition Dog Healthy 
ProteomicsLabel-free and targeted mass tandem (TMT-labelled) global proteomic analyses on mucus from the stomach, small and large intestine of pigLabel-free and targeted mass tandem (TMT-labelled) global proteomic analyses on mucus from the stomach, small and large intestine of pig
The gastrointestinal mucus is a hydrogel that lines the luminal side of the gastrointestinal epithelium, offering barrier protection from pathogens and lubrication of the intraluminal contents. These barrier properties likewise affect nutrients and drugs that need to penetrate the mucus to reach the...
ORGANISM(S): Sus scrofa (Pig) 
2022-03-07 | PXD029371 | Pride
Gastrointestinal Mucus Composition Healthy Porcine Pig 
ProteomicsSignaling mechanisms of the prototypical psychedelic LSD
Serotonin (5-hydroxytryptamine; 5-HT) 5-HT2-family receptors are the key targets of the prototypical psychedelic LSD. Although the canonical signaling pathway for 5-HT2 receptors is mediated by Gq protein, recent studies suggest that G-protein independent signaling, namely β-arrestin signaling pathw...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD030752 | Pride
Lc-msms 
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