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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
MetabolomicsBrown-fat-mediated tumour suppression by cold-altered global metabolism

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues. Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis. Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold an...

2022-08-12 | MTBLS4856 | MetaboLights
TranscriptomicsSurvival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3b phosphorylation
Platelet-derived growth factor-CC (PDGF-CC) is the third member of the PDGF family discovered after more than two decades of studies on the original members of the family, PDGF-AA and PDGF-BB. The biological function of PDGF-CC remains largely to be explored. We report here a novel finding that PDGF...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-19207 | biostudies-arrayexpress
ProteomicsIMPRINTS-CETSA, 5-FU in parental and 5-FU-resistant HCT15 cells
Parental and 5-fluorouracil (5-FU)-resistant HCT15 cells were treated with 5-FU or vehicle for 12h and assembled into an IMPRINTS-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC, 54ºC, and 57ºC) with each set of samples heated at one temperature included in the same isobar...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026472 | JPOST Repository
ProteomicsMCF7 xenografts with 5-FU in vivo ITDR-CETSA
MCF7 xenograft-bearing mice were treated intravenously for 22h with either vehicle or different 5-FU doses (10, 50, 100, and 150 mg/kg). Each xenograft was cut in similar-sized pieces and assembled into an ITDRCETSA scheme with 2 different heating temperatures (37ºC, 52ºC) and 3 xenograft pieces for...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026470 | JPOST Repository
ProteomicsIMPRINTS-CETSA, FUDR and FUR in MCF7 cells, 2h and 12h incubation
MCF7 cells were treated with floxuridine (FUDR), fluorouridine (FUR), or vehicle and assembled into an IMPRINTS-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC, 54ºC, and 57ºC) with each set of samples heated at one temperature included in the same isobaric TMT10 set and m...
ORGANISM(S): Homo Sapiens (human) 
2021-07-15 | PXD026471 | JPOST Repository
ProteomicsCo-IP and LC-MS/MS analysis for probing the binding partners of ITGBL1 in fibroblasts
Co-IP, LC-MS/MS and cluster analysis of the binding proteins for targeted ITGBL1 protein using the ITGBL1 antibody or control IgG in ITGBL1-overexpressing WI-38 cells.
ORGANISM(S): Homo Sapiens 
2020-01-19 | PXD017182 |
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
PXD056593 |
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