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Transcriptomicsm6A in 5’ untranslated regions promotes cap-independent translation of mRNA
N6-methyladenosine (m6A) is a widespread internal RNA modification whose function is poorly understood. Here we report that m6A residues within the 5'UTR promote a novel form of cap-independent translation which is mediated through an interaction between m6A residues and the translation initiation f...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-73405 | biostudies-arrayexpress
TranscriptomicsCharacterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5′ cap status
The mRNA 5′ cap is normally essential for eukaryotic mRNA translation, stabilization and transport and both the cap and eIF4E are important elements of post-transcriptional gene regulation. To further our understanding of mRNA translation in the human malaria parasite Plasmodium falciparum, we hav...
ORGANISM(S): Plasmodium falciparum 
2010-06-10 | E-GEOD-6356 | biostudies-arrayexpress
TranscriptomicsmRNAs translated at eIF4F
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end-dependent scanning to initiate translation, picornaviral, hepatitis C vi...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-62 | biostudies-arrayexpress
GenomicsAn mRNA cap-binding complex in giant viruses controls protein synthesis
An mRNA cap-binding complex in giant viruses controls protein synthesis
PRJNA1225729 | ENA
TranscriptomicsIdentification of re-capping substrates for the cytoplasmic capping enzyme complex
The analysis of capped RNAs by massively parallel sequencing has identified a large number of previously unknown transcripts, some of which are small RNAs and others are 5M-bM-^@M-^Y truncated forms of RefSeq genes. The latter may be generated by endonuclease cleavage or by stalling of Xrn1 at defi...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-36729 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of mRNAs from control and CAP-D3 deficient Salmonella infected HT-29 cells
BACKGROUND & AIMS- More frequent interaction of bacteria with the colonic epithelium is associated with ulcerative colitis (UC). The identities of all proteins which promote bacterial clearance in colonic epithelial cells are unknown. Previously, we discovered that dCAP-D3 (Chromosome Associated P...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-62520 | biostudies-arrayexpress
TranscriptomicsDevelopment of GRO-cap (GRO-seq followed by 5'-cap enrichment) to map transcription start sites in C. elegans
Dosage Compensation is required to correct for uneven gene dose between the sexes. We utilized global run-on sequencing (GRO-seq) to examine how Caenorhabditis elegans dosage compensation reduces transcription of X-linked genes. To facilitate these experiments, we required accurate 5M-bM-^@M-^Y-ends...
ORGANISM(S): Caenorhabditis elegans 
2013-06-18 | E-GEOD-43085 | biostudies-arrayexpress
ProteomicsDAP5 directs a widespread alternate form of cap-dependent mRNA translation initiation using eIF3d for specialized cell functions
Affinity purification of eIF4GII, eIF4GI and DAP5 using a HA tag on the N-terminus of each protein.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-05-25 | MSV000082407 | MassIVE
GenomicsCap-binding complex assists RNA Polymerase II transcription in plant salt stress response
Cap-binding complex assists RNA Polymerase II transcription in plant salt stress response
PRJNA836283 | ENA
ProteomicsLeishIF3d is a non-canonical cap-binding protein specific for Leishmania
Translation of most cellular mRNAs in eukaryotes proceeds through a cap-dependent pathway, whereby the cap-binding complex, eIF4F, anchors the pre-initiation complex at the 5’ end of mRNAs driving translation initiation. The genome of Leishmania encodes a large repertoire of cap-binding complexes th...
ORGANISM(S): Leishmania mexicana mexicana 
2023-07-20 | PXD040501 | Pride
Leishmania If3d 
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