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ProteomicsConditionally reprogrammed (CRC) and feeder free SMAD inhibited (SMADi) expanded human nasal epithelial cells label-free LC-MS/MS
Discovery of therapies that are able to correct defective CFTR requires patient derived in vitro pre-clinical cell models to be developed. Two main approaches exist to expand bronchial and nasal cultures, such as conditionally reprogrammed cells (CRC) and feeder free dual SMAD inhibition (SMADi) to ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-05 | PXD018386 | Pride
Human nasal epithelial cells Cystic fibrosis Conditionally reprogrammed cells Label-free lc-ms/ms Smad inhibition 
Proteomicsγ-glutamylcysteine (GGC) supplementation and p-LPS challenge causes distinct proteomic changes to primary airway epithelial cell models of Cystic Fibrosis
Cystic fibrosis (CF) is a life limiting inherited condition associated with recurrent bacterial infections, inflammation, oxidative stress and loss of lung function. CF is characterised by deficiencies in both intra- and extracellular glutathione (GSH) levels. This GSH depletion is exacerbated by ba...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019084 | Pride
Lps Glutathione Cystic fibrosis Airway epithelial cells Qlc-ms/ms Γ-glutamylcysteine Oxidative stress 
ProteomicsCentral bearded dragon hibernation label-free LC-MS/MS
Hibernation is a complex physiological state often exploited by animals under adverse environmental conditions. It involves large changes in metabolism and cellular function, with many stress responses modulated to tolerate physiological challenges that would otherwise be lethal. This study explores...
ORGANISM(S): Pogona vitticeps 
2019-04-18 | PXD011171 | Pride
Heart Brain Central bearded dragon Skeletal muscle Hibernation 
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