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MetabolomicsCapsaicin ameliorates glycemic levels via gut microbiota-derived 5-aminolevulinic acid in mice

Background: Capsaicin, a natural alkaloid in chili peppers, regulates glycemic levels, however, its mechanisms and therapeutic potential remain unclear. This study aimed to elucidate the role of gut microbiota and their metabolites in mediating capsaicin’s glycemic regulatory effects. We conducte...

2025-06-13 | MTBLS12575 | MetaboLights
MetabolomicsHigh-dose capsaicin exacerbates uveitis by disrupting intestinal ho-meostasis and upregulating IL-17
Purpose: To determine whether capsaicin (CAP) exacerbates experimental autoimmune uveitis (EAU) and whether this effect is associated with impaired intestinal homeostasis, gut microbiota re-modeling, and altered metabolic profiles. Methods: An EAU mouse model was used to evaluate the dose-dependent ...
2026-07-23 | MTBLS15144 | MetaboLights
ProteomicsProteomic profiling of capsaicin-induced relapse of chronic colitis
It has now been established that consumption of spicy food containing capsaicin is strongly associated with recurrence and worsening of symptoms in IBD.To uncover the potential signaling pathway involved in the capsaicin-induced relapse.To uncover the potential signaling pathway involved in the caps...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-03 | PXD032186 | Pride
Ibd Lc-ms Capsaicin Mice Colon 
TranscriptomicsMolecular effects of capsaicin on human gingival epithelial cells
In order to explain the molecular mechanisms of capsaicin-induced proliferation of gingival epithelial cells (GECs), a microarray analysis was performed. Several cell proliferation related genes were significantly up-regulated. These data suggest that TRPV1 signaling in GEC may induce transcriptiona...
ORGANISM(S): Homo sapiens 
2014-05-17 | E-GEOD-57759 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human gastric cancer cell line AGS treated with Capsaicin against DMSO
Capsaicin has previously been demonstrated to exhibit anti-tumor effect in various cancer type. However, the deep biological function and molecular mechanism of capsaicin was still uncertain. In this research, we used high-throughput RNA sequencing to unveil the potential biological function of caps...
ORGANISM(S): Homo sapiens 
2024-11-01 | E-MTAB-14511 | biostudies-arrayexpress
TranscriptomicsNociceptor HDAC4 regulates inflammatory pain
Transcriptional alterations are characteristic of persistent pain states but the key regulators remain elusive. Using a conditional knockout (cKO) strategy in mice we sought to determine whether loss of the transcriptional co-repressor histone deacetylase four (HDAC4) would have implications for sen...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-62405 | biostudies-arrayexpress
GenomicsTRPV1-Independent and Sex-Specific Capsaicin Signatures in Drosophila
TRPV1-Independent and Sex-Specific Capsaicin Signatures in Drosophila
PRJNA1308527 | ENA
TranscriptomicsCapsaicin treatment with 250 ppm for 2 h
The number and type of synthetic chemicals that are being produced worldwide continues to increase significantly. While these industrial chemicals provide numerous benefits, there is no doubt that some have potential to damage the environment and health. Toxicity must be evaluated and use must be ca...
ORGANISM(S): Saccharomyces cerevisiae 
2007-11-01 | GSE9360 | GEO
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis Transcriptomes of dHL-60 cells after capsaicin processed
To uncoverthe capsaicin effects on the neutrophil activation, we performed transcriptomic of dHL-60 cells after capsaicin stimulation in degree of different time. this study revealed the functional changes of neutrophils in the presence of capsaicin. The transcriptomic data with different time stimu...
ORGANISM(S): Homo sapiens 
2022-06-30 | GSE198304 | GEO
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis Transcriptomes of dHL-60 cells after capsaicin processed
Next Generation Sequencing Facilitates Quantitative Analysis Transcriptomes of dHL-60 cells after capsaicin processed
PRJNA814524 | ENA
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